Obesity and breast cancer: A complex relationship

被引：13
作者：
Gershuni V.M. [1 ]
Ahima R.S. [2 ]
Tchou J. [3 ]
机构：
[1] Department of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, 4 Maloney, Philadelphia, 19104, PA
[2] Department of Endocrinology, Diabetes and Metabolism Division, Hospital of the University of Pennsylvania, 3400 Civic Center Boulevard, Building 421, Philadelphia, 19104, PA
[3] Department of Surgery Division of Endocrine and Oncologic Surgery, Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine, 34th & Civic Center Blvd, 3 South, Philadelphia, 19104, PA
来源：
Current Surgery Reports | / 4卷 / 4期
关键词：
Adipocyte; Adipokines; Adiponectin; Aromatase; BMI; Breast cancer; Estrogen receptor Leptin; Hyperglycemia; Hyperinsulinemia; Inflammation; Insulin resistance; Metabolic syndrome; Obesity; Overweight;
D O I：
10.1007/s40137-016-0134-5
中图分类号：
学科分类号：
摘要：
As prevalence of obesity continues to rise in the United States, we are beginning to elucidate the complex role of obesity-associated chronic inflammation, endocrine dysfunction, and hormone production as a driver for increased breast cancer risk. Epidemiological data suggest that obesity (BMI [ 30) is associated with increased breast cancer incidence, worse prognosis, and higher mortality rates. Mechanistically, obesity and excess fat mass represent a state of chronic inflammation, insulin resistance, adipokine imbalance, and increased estrogen signaling. This pro-tumorigenic environment stimulates cancer development through abnormal growth, proliferation, and survival of mammary tissue. Importantly, obesity is a modifiable risk factor; alterations in cell proliferation, apoptosis, circulating estrogen, and insulin sensitivity are observed in response to weight loss attainable through behavior modification including dietary and exercise changes. © Springer Science + Business Media New York 2016.
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