The potential of therapeutic strategies targeting mitochondrial biogenesis for the treatment of insulin resistance and type 2 diabetes mellitus

被引:0
作者
Wenwen Ding
Xiaoxue Yang
Kaiyi Lai
Yu Jiang
Ying Liu
机构
[1] Beijing University of Chinese Medicine,School of Life Sciences
[2] University of Pittsburgh,Department of Pharmacology and Chemical Biology, School of Medicine
来源
Archives of Pharmacal Research | 2024年 / 47卷
关键词
Mitochondrial biogenesis; Type 2 diabetes mellitus; Diabetic complications; Insulin resistance; Natural products;
D O I
暂无
中图分类号
学科分类号
摘要
Type 2 diabetes mellitus (T2DM) is a persistent metabolic disorder marked by deficiencies in insulin secretion and/or function, affecting various tissues and organs and leading to numerous complications. Mitochondrial biogenesis, the process by which cells generate new mitochondria utilizing existing ones plays a crucial role in energy homeostasis, glucose metabolism, and lipid handling. Recent evidence suggests that promoting mitochondrial biogenesis can alleviate insulin resistance in the liver, adipose tissue, and skeletal muscle while improving pancreatic β-cell function. Moreover, enhanced mitochondrial biogenesis has been shown to ameliorate T2DM symptoms and may contribute to therapeutic effects for the treatment of diabetic nephropathy, cardiomyopathy, retinopathy, and neuropathy. This review summarizes the intricate connection between mitochondrial biogenesis and T2DM, highlighting the potential of novel therapeutic strategies targeting mitochondrial biogenesis for T2DM treatment and its associated complications. It also discusses several natural products that exhibit beneficial effects on T2DM by promoting mitochondrial biogenesis.
引用
收藏
页码:219 / 248
页数:29
相关论文
共 1413 条
[81]  
Sakamoto T(2019)Omega-3 fatty acids and adipose tissue: inflammation and browning Nat Rev Endocrinol 15 105-4899
[82]  
Xiao F(2011)Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats Antioxid Redox Signal 15 2779-297
[83]  
VanDusen NJ(2015)Melatonin in type 2 diabetes mellitus and obesity Vascul Pharmacol 71 11-532
[84]  
Zhou PZ(2020)Cocoa and chocolate in human health and disease Nutr Neurosci 23 281-614
[85]  
Sweat ME(2023)The cardiovascular benefits of dark chocolate Int Immunopharmacol 116 109793-210
[86]  
Wang Y(2018)The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection Pflugers Arch 470 263-196
[87]  
Prondzynski M(2007)Piceatannol promotes neuroprotection by inducing mitophagy and mitobiogenesis in the experimental diabetic peripheral neuropathy and hyperglycemia-induced neurotoxicity Diabetes 56 2973-793
[88]  
Chen J(2010)Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts Dtsch Arztebl Int 107 75-994
[89]  
Zhang Y(2018)Essential role of mitochondrial function in adiponectin synthesis in adipocytes J Agric Food Chem 66 11917-189
[90]  
Wang PZ(2015)Diabetic retinopathy: early diagnosis and effective treatment Prog Retin Eye Res 48 40-R1192