Nanoparticle-Based Chimeric Antigen Receptor Therapy for Cancer Immunotherapy

被引：0
|
作者：
Seungyong Shin
Pyunghwajun Lee
Jieun Han
Se-Na Kim
Jaesung Lim
Dae-Hwan Park
Taejong Paik
Junhong Min
Chun Gwon Park
Wooram Park
机构：
[1] Sungkyunkwan University,Department of Integrative Biotechnology, College of Biotechnology and Bioengineering
[2] SKKU Institute for Convergence,Department of Global Biomedical Engineering
[3] Sungkyunkwan University (SKKU),Institute of Biotechnology and Bioengineering, College of Biotechnology and Bioengineering
[4] Sungkyunkwan University,Institute of Medical and Biological Engineering, Medical Research Center
[5] Seoul National University,Department of Intelligent Precision Healthcare Convergence
[6] SKKU Institute for Convergence,Department of Engineering Chemistry
[7] Sungkyunkwan University (SKKU),School of Integrative Engineering
[8] Chungbuk National University,Biomedical Institute for Convergence at SKKU (BICS)
[9] Chung-Ang University,undefined
[10] Sungkyunkwan University,undefined
来源：
Tissue Engineering and Regenerative Medicine | 2023年 / 20卷
关键词：
Chimeric antigen receptor (CAR); Nanoparticle; Genetic engineering; Immune cell reprograming; Cancer immunotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) has emerged as an innovative immunotherapy for hematological cancer treatment. However, the limited effect on solid tumors, complex processes, and excessive manufacturing costs remain as limitations of CAR-T therapy. Nanotechnology provides an alternative to the conventional CAR-T therapy. Owing to their unique physicochemical properties, nanoparticles can not only serve as a delivery platform for drugs but also target specific cells. Nanoparticle-based CAR therapy can be applied not only to T cells but also to CAR-natural killer and CAR-macrophage, compensating for some of their limitations. This review focuses on the introduction of nanoparticle-based advanced CAR immune cell therapy and future perspectives on immune cell reprogramming.
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页码：371 / 387
页数：16
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