CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B

被引：0
|
作者：
Yuejiao Dong
Xuefen Li
Lu Zhang
Qiaoyun Zhu
Chunlei Chen
Jiaqi Bao
Yu Chen
机构：
[1] Zhejiang University,Department of Laboratory Medicine, Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, First Affiliated Hospital, College of Medicine
[2] Zhejiang University,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine
来源：
BMC Immunology | / 20卷
关键词：
CD4; T cells; Chronic HBV infection; Inhibitory molecules; Programmed death 1 (PD-1); Lymphocyte activation gene-3 (LAG-3); Cytokine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] CD4+ T cell exhaustion revealed by high PD-1 and LAG-3 expression and the loss of helper T cell function in chronic hepatitis B
    Dong, Yuejiao
    Li, Xuefen
    Zhang, Lu
    Zhu, Qiaoyun
    Chen, Chunlei
    Bao, Jiaqi
    Chen, Yu
    BMC IMMUNOLOGY, 2019, 20 (01)
  • [2] PD-1 and LAG-3: synergistic fostering of T cell exhaustion
    Hofmann, Maike
    Thimme, Robert
    Schamel, Wolfgang W.
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 9 (01)
  • [3] CD4+ T Helper Cell Populations with High PD-1 Expression Are Expanded in Systemic Sclerosis
    Mueller, Alisa
    Fava, Andrea
    Rao, Deepak
    Boin, Francesco
    ARTHRITIS & RHEUMATOLOGY, 2019, 71
  • [4] Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection
    Tomohiro Okagawa
    Satoru Konnai
    Asami Nishimori
    Naoya Maekawa
    Shinya Goto
    Ryoyo Ikebuchi
    Junko Kohara
    Yasuhiko Suzuki
    Shinji Yamada
    Yukinari Kato
    Shiro Murata
    Kazuhiko Ohashi
    Veterinary Research, 49
  • [5] Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection
    Okagawa, Tomohiro
    Konnai, Satoru
    Nishimori, Asami
    Maekawa, Naoya
    Goto, Shinya
    Ikebuchi, Ryoyo
    Kohara, Junko
    Suzuki, Yasuhiko
    Yamada, Shinji
    Kato, Yukinari
    Murata, Shiro
    Ohashi, Kazuhiko
    VETERINARY RESEARCH, 2018, 49 : 50
  • [6] Expression of PD-1/LAG-3 and cytokine production by CD4+ T cells during infection with Plasmodium parasites
    Doe, Henrietta T.
    Kimura, Daisuke
    Miyakoda, Mana
    Kimura, Kazumi
    Akbari, Masoud
    Yui, Katsuyuki
    MICROBIOLOGY AND IMMUNOLOGY, 2016, 60 (02) : 121 - 131
  • [7] No more LAGging behind PD-1: uncovering the unique role of LAG-3 in T-cell exhaustion
    Jo, Yunju
    Jin, Hyung-seung
    Park, Yoon
    CELLULAR & MOLECULAR IMMUNOLOGY, 2024, 21 (12) : 1351 - 1353
  • [8] Cooperation of PD-1 and LAG-3 Contributes to T-Cell Exhaustion in Anaplasma marginale-Infected Cattle
    Okagawa, Tomohiro
    Konnai, Satoru
    Deringer, James R.
    Ueti, Massaro W.
    Scoles, Glen A.
    Murata, Shiro
    Ohashi, Kazuhiko
    Brown, Wendy C.
    INFECTION AND IMMUNITY, 2016, 84 (10) : 2779 - 2790
  • [9] CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART
    Fromentin, Remi
    Bakeman, Wendy
    Lawani, Mariam B.
    Khoury, Gabriela
    Hartogensis, Wendy
    DaFonseca, Sandrina
    Killian, Marisela
    Epling, Lorrie
    Hoh, Rebecca
    Sinclair, Elizabeth
    Hecht, Frederick M.
    Bacchetti, Peter
    Deeks, Steven G.
    Lewin, Sharon R.
    Sekaly, Rafick-Pierre
    Chomont, Nicolas
    PLOS PATHOGENS, 2016, 12 (07)
  • [10] PD-1 expression is markedly upregulated on intratumoral CD4+ and CD8+ T cells in follicular lymphoma and is associated with T-Cell exhaustion
    Nattamai, Durgha
    Neelapu, Sattva S.
    BLOOD, 2007, 110 (11) : 808A - 808A
12345