RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening

被引：0

作者：

Chung Liang Lim

Toshihiko Nogawa

Masakazu Uramoto

Akiko Okano

Yayoi Hongo

Takemichi Nakamura

Hiroyuki Koshino

Shunji Takahashi

Darah Ibrahim

Hiroyuki Osada

机构：

[1] Antibiotics Laboratory,

[2] RIKEN,undefined

[3] Industrial Biotechnology Research Laboratory,undefined

[4] School of Biological Sciences,undefined

[5] Universiti Sains Malaysia,undefined

[6] RIKEN Center for Sustainable Research Science,undefined

[7] RIKEN Global Research Cluster,undefined

来源：

The Journal of Antibiotics | 2014年 / 67卷

关键词：

antimicrobial activities; fraction library; microbial metabolites; quinomycin; spectral database; sp.; structure elucidation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Two novel quinomycin derivatives, RK-1355A (1) and B (2), and one known quinomycin derivative, UK-63,598 (3), were isolated from a microbial metabolites fraction library of Streptomyces sp. RK88-1355 based on Natural Products Plot screening. The structural elucidation of 1 and 2 was established through two-dimensional NMR and mass spectrometric measurements. They belong to a class of quinomycin antibiotics family having 3-hydroxyquinaldic acid and a sulfoxide moiety. They are the first examples for natural products as a quinoline type quinomycin having a sulfoxide on the intramolecular cross-linkage. They showed potent antiproliferative activities against various cancer cell lines and they were also found to exhibit moderate antibacterial activity.

引用

页码：323 / 329

页数：6

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