Chromatin replication and epigenetic cell memory

被引:0
作者
Kathleen R. Stewart-Morgan
Nataliya Petryk
Anja Groth
机构
[1] University of Copenhagen,The Novo Nordisk Foundation Center for Protein Research (CPR)
[2] University of Copenhagen,Biotech Research and Innovation Centre (BRIC)
[3] Epigenetics and Cell Fate,undefined
[4] UMR7216 CNRS,undefined
[5] University of Paris,undefined
来源
Nature Cell Biology | 2020年 / 22卷
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摘要
Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division.
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页码:361 / 371
页数:10
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