Synthesis and study of antibacterial and antifungal activities of Novel 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl] acetylamino]thiazoles

被引：0
|
作者：
Zafer Asim Kaplancikli
Gülhan Turan-Zitouni
Gilbert Revial
Kiymet Guven
机构：
[1] CNRS (ESA 7084) ESPCI,Laboiratoire de Chimie Organique
[2] Anadolu University,Department of Biology
[3] Faculty of Science,Department of Pharmaceutical Chemistry
[4] Anadolu University,undefined
[5] Faculty of Pharmacy,undefined
来源：
Archives of Pharmacal Research | 2004年 / 27卷
关键词：
Thiazole; Benzoxazole; Benzimidazole; Antimicrobial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of K2CO3. The chemical structures of the compounds were elucidated by IR,1H-NMR, and FAB+-MS spectral data. Their antimicrobial activities againstMicrococcus luteus (NRLL B-4375),Bacillus cereus (NRRL B-3711),Proteus vulgaris (NRRL B-123),Salmonella typhimurium (NRRL B-4420),Staphylococcus aureus (NRRL B-767),Escherichia coli (NRRL B-3704),Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac.of Medicine) were investigated and in this investigation, a significant level of activity was illustrated.
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页码：1081 / 1085
页数：4
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