Synthesis and study of antibacterial and antifungal activities of Novel 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl] acetylamino]thiazoles

被引：0

作者：

Zafer Asim Kaplancikli

Gülhan Turan-Zitouni

Gilbert Revial

Kiymet Guven

机构：

[1] CNRS (ESA 7084) ESPCI,Laboiratoire de Chimie Organique

[2] Anadolu University,Department of Biology

[3] Faculty of Science,Department of Pharmaceutical Chemistry

[4] Anadolu University,undefined

[5] Faculty of Pharmacy,undefined

来源：

Archives of Pharmacal Research | 2004年 / 27卷

关键词：

Thiazole; Benzoxazole; Benzimidazole; Antimicrobial activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Several 2-[[(benzoxazole/benzimidazole-2-yl)sulfanyl]acetylamino]thiazoles derivatives were synthesized by reacting 4-substituted-2-(chloroacetylamino)thiazoles with benzoxazole/benzimidazole-2-thioles in acetone and in the presence of K2CO3. The chemical structures of the compounds were elucidated by IR,1H-NMR, and FAB+-MS spectral data. Their antimicrobial activities againstMicrococcus luteus (NRLL B-4375),Bacillus cereus (NRRL B-3711),Proteus vulgaris (NRRL B-123),Salmonella typhimurium (NRRL B-4420),Staphylococcus aureus (NRRL B-767),Escherichia coli (NRRL B-3704),Candida albicans and Candida globrata (isolates obtained from Osmangazi Uni. Fac.of Medicine) were investigated and in this investigation, a significant level of activity was illustrated.

引用

页码：1081 / 1085

页数：4

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