Synthesis of novel 3-[5-ethyl-2-(2-phenoxy-ethyl)-pyridin]-5-substituted isoxazoline libraries via 1,3-dipolar cycloaddition and evaluation of antimicrobial activities

被引：0
作者：
S.L. Gaonkar
K.M. Lokanatha Rai
B. Prabhuswamy
机构：
[1] University of Mysore,Department of Studies in Chemistry
来源：
Medicinal Chemistry Research | 2007年 / 15卷
关键词：
Isoxazolines; Antimicrobial activity; Chloramine-T; 1,3-dipolar cycloaddition;
D O I：
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中图分类号：
学科分类号：
摘要：
A series of novel 3-[5-ethyl-2-(2-phenoxy-ethyl)-pyridin]-5-substituted isoxazolines were synthesized via 1,3-dipolar cycloaddition of in situ generated nitrile oxide from 4-[2-(5-ethylpyridyl)-ethoxy]-benzaldoxime with alkenes to obtain new heterocyclic libraries containing a pyridine moiety in addition to the isoxazoline ring. The newly synthesized compounds were screened for their antimicrobial activity and were compared with standard drugs. The compounds demonstrated potent to weak antimicrobial activity. Of the compounds studied, compounds 3c and 3f showed significant antibacterial as well as antifungal activity. Compounds 3e and 3g showed moderate activity. The title compounds represent a novel class of potent antimicrobial agents.
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页码：407 / 417
页数：10
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