Adherence to Antiretroviral Therapy Among Children Living with HIV in South India

被引：0
作者：
K. Mehta
M. L. Ekstrand
E. Heylen
G. N. Sanjeeva
A. Shet
机构：
[1] St. John’s Medical College Hospital,Division of Infectious Diseases, Department of Pediatrics
[2] University of California San Francisco,Department of Medicine
[3] Indira Gandhi Institute of Child Health,Department of Pediatrics
[4] St. John’s Research Institute,Department of Public Health Sciences
[5] Karolinska Institutet,undefined
来源：
AIDS and Behavior | 2016年 / 20卷
关键词：
Adherence; Children; HIV; Antiretroviral therapy; Virological failure;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Adherence to ART, fundamental to treatment success, has been poorly studied in India. Caregivers of children attending HIV clinics in southern India were interviewed using structured questionnaires. Adherence was assessed using a visual analogue scale representing past-month adherence and treatment interruptions >48 h during the past 3 months. Clinical features, correlates of adherence and HIV-1 viral-load were documented. Based on caregiver reports, 90.9 % of the children were optimally adherent. In multivariable analysis, experiencing ART-related adverse effects was significantly associated with suboptimal adherence (p = 0.01). The proportion of children who experienced virological failure was 16.5 %. Virological failure was not linked to suboptimal adherence. Factors influencing virological failure included running out of medications (p = 0.002) and the child refusing to take medications (p = 0.01). Inclusion of drugs with better safety profiles and improved access to care could further enhance outcomes.
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页码：1076 / 1083
页数：7
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