Association Between Alzheimer Disease and the −491T Allele of Regulatory Region Polymorphism of Apolipoprotein E in a Tunisian Population

被引：0
作者：
Afef Achouri-Rassas
Sondes Hadj Fredj
Hela Mrabet Khiari
Amina Bibi
Hajer Siala
Amel Mrabet
Taieb Messaoud
机构：
[1] Charles Nicolle Hospital,Neurological Department
[2] Children’s Hospital,Biochemistry and Molecular Biology Laboratory
来源：
Neurochemical Research | 2014年 / 39卷
关键词：
Alzheimer disease; Apolipoprotein E; −491A/T polymorphism; Risk factor;
D O I：
暂无
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学科分类号：
摘要：
The apolipoprotein E (APOE) is a well-established risk factor for late-onset Alzheimer’s disease (AD). Several studies have attempted to confirm the association between the polymorphism located at position −491 in the transcriptional regulatory region of the APOE gene and AD. We examined in 85 AD patients and 90 control subjects of a Tunisian population the potential involvement of this polymorphism as a risk factor for AD, either through an independent effect or through interaction with the existing APOE ε4 allele risk. The T allele frequency was significantly higher in the AD patients group (45.3 %) than in the controls group (32.78 %) and may possibly constitute a significant risk factor for AD. The APOE ε4 allele did not influence the distribution of the −491 polymorphism after stratification.
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页码：244 / 247
页数：3
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  • [1] Valenza A(2010)The APOE −491A/T promoter polymorphism effect on cognitive profile of Alzheimer’s patients Neurosci Lett 472 199-203
  • [2] Bizzarro A(2008)Apolipoprotein E promoter polymorphisms (−491A/T and −427T/C) and Alzheimer’s disease: no evidence of association in the Irish population Ir J Med Sci 177 29-33
  • [3] Marra C(1993)Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families Science 261 921-923
  • [4] Lauria A(2010)Apolipoprotein E promoter polymorphisms and risk of Alzheimer’s disease: evidence from meta-analysis J Alzheimers Dis 19 1283-1294
  • [5] Guglielmi V(2012)High APOE epsilon 4 allele frequencies associated with Alzheimer disease in a Tunisian population Neurol Sci 33 33-37
  • [6] Rossi C(1984)Clinical diagnosis of Alzheimer’s disease: report of the NINCDS–ADRDA work group under the auspices of department of health and human services task force on Alzheimer’s disease Neurology 34 939-944
  • [7] Tiziano FD(1999)Different procedures for the isolation of DNA from blood samples Ann Biol Clin (Paris) 57 77-84
  • [8] Brahe C(1990)Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI J Lipid Res 31 545-548
  • [9] Masullo C(2001)The –491TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer’s disease Neurosci Lett 304 204-208
  • [10] Lynch CA(1998)Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene FEBS Lett 421 105-108
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