Localized Tongue Amyloidosis in a Patient with Neurofibromatosis Type II

被引：15
作者：
Andreadis D. [1 ]
Poulopoulos A. [1 ]
Papadopoulos P. [1 ]
Epivatianos A. [1 ]
机构：
[1] Department of Oral Medicine/Pathology, School of Dentistry, Aristotle University of Thessaloniki
来源：
Head and Neck Pathology | 2011年 / 5卷 / 3期
关键词：
Neurofibromatosis type II; Oral amyloidosis;
D O I：
10.1007/s12105-011-0251-5
中图分类号：
学科分类号：
摘要：
Background: Localized Amyloidosis (AL) may rarely involve oral mucosa. This is the first known reported case describing the development of tongue AL in a 30-year-old patient with Neurofibromatosis (NF) type-2. Case: A female patient presented with a painless, well-circumscribed nodule of the tongue. Her medical history included NF type-2 with chromosome-22 abnormal karyotype (mosaicism), multiple intracranial and spinal meningiomas/schwannomas and unilateral blindness/deafness. The biopsy of the excised lesion of the tongue revealed subepithelial accumulation of an amorphous, nodular, fibrillar material positive for Congo red. Blood examination showed increased Thyroxine-T4 due to thyroid multinodular colloid goiter, but excluded any other hematological/immunological disorder or organ dysfunction. No recurrence was observed after a six-month follow-up. Conclusion: This case highlights the possibility of oral manifestations as the only sign of AL and reveals the unexpected co-existence of AL and NF 2, for the first time. © 2011 Springer Science+Business Media, LLC.
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页码：302 / 305
页数：3
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