Comparison of quantitative analytical methods in headspace gas chroamtography of residual solvents

被引：0

作者：

A. Naddaf

J. Balla

机构：

[1] Technical University of Budapest,Institute of General and Analytical Chemistry, Chemical Instrumentation Centre of the National Scientific Research Fund

来源：

Chromatographia | 2000年 / 51卷

关键词：

Gas chromatography; Static headspace; Quantitative HS-GC; Comparison of quantitative methods;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The aim of this work was to compare quantitative methods used for headspace gas chromatographic analysis of residual solvents in standard aqueous solutions and to apply the methods to the analysis of medicines. We found that all three quantitative methods (external standard, ESTD; internal standard, ISTD; and standard addition, ASTD) enable determination of the total amount of solute in the equilibrated system by analysis of defined volumes of headspace gas. The results showed that the ISTD method is more precise than ESTD and ASTD when there is no strong interaction between the residual solvents and the pharmaceutical base material. When, however, there is a strong polarpolar interaction between them, the ESTD and ISTD methods give worse results than the ASTD method, because the ASTD method can eliminate the matrix effect.

引用

页码：S241 / S248