Investigation of Color in a Fusion Protein Using Advanced Analytical Techniques: Delineating Contributions from Oxidation Products and Process Related Impurities

被引:0
作者
Hangtian Song
Jianlin Xu
Mi Jin
Chao Huang
Jacob Bongers
He Bai
Wei Wu
Richard Ludwig
Zhengjian Li
Li Tao
Tapan K. Das
机构
[1] Bristol-Myers Squibb,Biologics Molecular and Analytical Development
[2] Bristol-Myers Squibb,Biologics Process Development
[3] Bristol-Myers Squibb,Biologics Molecular and Analytical Development
[4] Bristol-Myers Squibb,Biologics Process Development
来源
Pharmaceutical Research | 2016年 / 33卷
关键词
color; histidine; mass spectrometry; oxidation; process development; tryptophan; ultra-performance liquid chromatography;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:932 / 941
页数:9
相关论文
共 204 条
[1]  
Shire SJ(2004)Challenges in the development of high protein concentration formulations J Pharm Sci 93 1390-1402
[2]  
Shahrokh Z(2004)Opalescent appearance of an IgG1 antibody at high concentrations and its relationship to noncovalent association Pharm Res 21 1087-1093
[3]  
Liu J(2010)Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation J Pharm Sci 99 82-93
[4]  
Sukumar M(2011)Opalescence of an IgG2 monoclonal antibody solution as it relates to liquid–liquid phase separation J Pharm Sci 100 4587-4596
[5]  
Doyle B(2006)Cofactor-containing antibodies: Crystal structure of the original yellow antibody Proc Natl Acad Sci U S A 103 3581-3585
[6]  
Combs J(2013)Hydroxocobalamin association during cell culture results in pink therapeutic proteins MAbs 5 974-981
[7]  
Pekar A(1972)Fluorescence of N′-formylkynurenine and of protein exposed to sunlight Biochem J 128 1365-1367
[8]  
Salinas BA(1971)Formation of N′-formylkynurenine in proteins from lens and other sources by exposure to sunlight Biochem J 125 203-208
[9]  
Sathish HA(1984)Photochemistry of proteins: a Review Curr Eye Res 3 137-144
[10]  
Bishop SM(1999)Human lens coloration and aging: evidence for crystallin modification by the major ultraviolet filter, 3-hydroxy-kynurenineo-Β-D-glucoside J Biol Chem 274 32547-32550