Investigation of Color in a Fusion Protein Using Advanced Analytical Techniques: Delineating Contributions from Oxidation Products and Process Related Impurities

[1] Shire SJ(2004)Challenges in the development of high protein concentration formulations J Pharm Sci 93 1390-1402

[2] Shahrokh Z(2004)Opalescent appearance of an IgG1 antibody at high concentrations and its relationship to noncovalent association Pharm Res 21 1087-1093

[3] Liu J(2010)Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation J Pharm Sci 99 82-93

[4] Sukumar M(2011)Opalescence of an IgG2 monoclonal antibody solution as it relates to liquid–liquid phase separation J Pharm Sci 100 4587-4596

[5] Doyle B(2006)Cofactor-containing antibodies: Crystal structure of the original yellow antibody Proc Natl Acad Sci U S A 103 3581-3585

[6] Combs J(2013)Hydroxocobalamin association during cell culture results in pink therapeutic proteins MAbs 5 974-981

[7] Pekar A(1972)Fluorescence of N′-formylkynurenine and of protein exposed to sunlight Biochem J 128 1365-1367

[8] Salinas BA(1971)Formation of N′-formylkynurenine in proteins from lens and other sources by exposure to sunlight Biochem J 125 203-208

[9] Sathish HA(1984)Photochemistry of proteins: a Review Curr Eye Res 3 137-144

[10] Bishop SM(1999)Human lens coloration and aging: evidence for crystallin modification by the major ultraviolet filter, 3-hydroxy-kynurenineo-Β-D-glucoside J Biol Chem 274 32547-32550

[1] Shire SJ(2004)Challenges in the development of high protein concentration formulations J Pharm Sci 93 1390-1402

[2] Shahrokh Z(2004)Opalescent appearance of an IgG1 antibody at high concentrations and its relationship to noncovalent association Pharm Res 21 1087-1093

[3] Liu J(2010)Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation J Pharm Sci 99 82-93

[4] Sukumar M(2011)Opalescence of an IgG2 monoclonal antibody solution as it relates to liquid–liquid phase separation J Pharm Sci 100 4587-4596

[5] Doyle B(2006)Cofactor-containing antibodies: Crystal structure of the original yellow antibody Proc Natl Acad Sci U S A 103 3581-3585

[6] Combs J(2013)Hydroxocobalamin association during cell culture results in pink therapeutic proteins MAbs 5 974-981

[7] Pekar A(1972)Fluorescence of N′-formylkynurenine and of protein exposed to sunlight Biochem J 128 1365-1367

[8] Salinas BA(1971)Formation of N′-formylkynurenine in proteins from lens and other sources by exposure to sunlight Biochem J 125 203-208

[9] Sathish HA(1984)Photochemistry of proteins: a Review Curr Eye Res 3 137-144

[10] Bishop SM(1999)Human lens coloration and aging: evidence for crystallin modification by the major ultraviolet filter, 3-hydroxy-kynurenineo-Β-D-glucoside J Biol Chem 274 32547-32550