Anti-cancer activity of new benzyl isoquinoline alkaloid from Saudi plant Annona squamosa

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作者：
Adel M. Al-ghazzawi
机构：
[1] King Khalid University,Department of Chemistry
来源：
BMC Chemistry | / 13卷
关键词：
Annonacea; (6, 7-dimethoxy-1-(α-hydroxy-4-methoxybenzyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinolin; Coclaurine;
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摘要：
Two alkaloids, belonging to benzylisoquinoline alkaloids, were isolated from Annona squamosa. One of these alkaloids, 6, 7-dimethoxy-1-(α-hydroxy-4-methoxybenzyl)-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline, was isolated for the first time from natural sources, while, the alkaloid, Coclaurine was known in Annona squamosa L. Moreover, the isolated alkaloids tested for the anti-cancer activities on various cell lines (HepG-2, MCF-7, and HCT-116). [graphic not available: see fulltext]
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