Personalized medicine in psychiatry: problems and promises

被引：0

作者：

Uzoezi Ozomaro

Claes Wahlestedt

Charles B Nemeroff

机构：

[1] Leonard M. Miller School of Medicine,University of Miami

[2] Hussman Institute for Human Genomics,Center for Therapeutic Innovation

[3] University of Miami Miller School of Medicine,Department of Psychiatry and Behavioral Sciences

[4] University of Miami,undefined

[5] Leonard M. Miller School of Medicine,undefined

来源：

BMC Medicine | / 11卷

关键词：

Major depressive disorder; Schizophrenia; Personalized medicine; Psychiatric hereditability; Epigenetics; Environmental factors; Endophenotypes; Pharmacogenomics; Neuroimaging genetics;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The central theme of personalized medicine is the premise that an individual’s unique physiologic characteristics play a significant role in both disease vulnerability and in response to specific therapies. The major goals of personalized medicine are therefore to predict an individual’s susceptibility to developing an illness, achieve accurate diagnosis, and optimize the most efficient and favorable response to treatment. The goal of achieving personalized medicine in psychiatry is a laudable one, because its attainment should be associated with a marked reduction in morbidity and mortality. In this review, we summarize an illustrative selection of studies that are laying the foundation towards personalizing medicine in major depressive disorder, bipolar disorder, and schizophrenia. In addition, we present emerging applications that are likely to advance personalized medicine in psychiatry, with an emphasis on novel biomarkers and neuroimaging.

引用