Assessing the nonlinear association of environmental factors with antibiotic resistance genes (ARGs) in the Yangtze River Mouth, China

被引：7

作者：

Miao J. ^{[1
,2
]}

Ling Y. ^{[1
,3
]}

Chen X. ^{[1
,4
]}

Wu S. ^{[1
,5
]}

Liu X. ^{[1
]}

Xu S. ^{[1
,6
]}

Umar S. ^{[1
,6
]}

Anderson B.D. ^{[1
,6
,7
]}

机构：

[1] Division of Natural and Applied Science, Duke Kunshan University, Jiangsu, Kunshan

[2] Department of Biomedical Informatics, Harvard Medical School, Boston, MA

[3] Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD

[4] Department of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD

[5] Department of Statistics, University of Michigan, Ann Arbor, MI

[6] Global Health Research Center, Duke Kunshan University, Jiangsu, Kunshan

[7] Department of Environmental and Global Health, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, 32610, FL

来源：

Scientific Reports | / 13卷 / 1期

关键词：

D O I：

10.1038/s41598-023-45973-9

中图分类号：

学科分类号：

摘要：

The emergence of antibacterial resistance (ABR) is an urgent and complex public health challenge worldwide. Antibiotic resistant genes (ARGs) are considered as a new pollutant by the WHO because of their wide distribution and emerging prevalence. The role of environmental factors in developing ARGs in bacterial populations is still poorly understood. Therefore, the relationship between environmental factors and bacteria should be explored to combat ABR and propose more tailored solutions in a specific region. Here, we collected and analyzed surface water samples from Yangtze Delta, China during 2021, and assessed the nonlinear association of environmental factors with ARGs through a sigmoid model. A high abundance of ARGs was detected. Amoxicillin, phosphorus (P), chromium (Cr), manganese (Mn), calcium (Ca), and strontium (Sr) were found to be strongly associated with ARGs and identified as potential key contributors to ARG detection. Our findings suggest that the suppression of ARGs may be achieved by decreasing the concentration of phosphorus in surface water. Additionally, Group 2A light metals (e.g., magnesium and calcium) may be candidates for the development of eco-friendly reagents for controlling antibiotic resistance in the future. © 2023, The Author(s).

引用

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