Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway

被引：0
|
作者：
Meichen Ma
Yue Pan
Yue Zhang
Mei Yang
Ying Xi
Baoxu Lin
Wudi Hao
Jianhua Liu
Lina Wu
Yong Liu
Xiaosong Qin
机构：
[1] Shengjing Hospital of China Medical University,Department of Laboratory Medicine
来源：
Journal of Cell Communication and Signaling | 2023年 / 17卷
关键词：
Idiopathic membranous nephropathy; Metformin; Rapamycin; AMPK/mTOR;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1405 / 1415
页数：10
相关论文
共 50 条
  • [21] Dapagliflozin alleviates advanced glycation end product induced podocyte injury through AMPK/mTOR mediated autophagy pathway
    Yang, Lei
    Liang, Baozhu
    Li, Jingxin
    Zhang, Xiaoyan
    Chen, Hong
    Sun, Jia
    Zhang, Zhen
    CELLULAR SIGNALLING, 2022, 90
  • [22] C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy
    Zhang, Qi
    Bin, Sofia
    Budge, Kelly
    Petrosyan, Astgik
    Villani, Valentina
    Aguiari, Paola
    Vink, Coralien
    Wetzels, Jack
    Soloyan, Hasmik
    La Manna, Gaetano
    Podesta, Manuel Alfredo
    Molinari, Paolo
    Sedrakyan, Sargis
    Lemley, Kevin V.
    De Filippo, Roger E.
    Perin, Laura
    Cravedi, Paolo
    Da Sacco, Stefano
    JCI INSIGHT, 2024, 9 (04)
  • [23] Exogenous NADPH ameliorates myocardial ischemia-reperfusion injury in rats through activating AMPK/mTOR pathway
    Zhu, Jiang
    Wang, Yi-fei
    Chai, Xiao-ming
    Qian, Ke
    Zhang, Ling-wei
    Peng, Peng
    Chen, Pei-min
    Cao, Jian-fang
    Qin, Zheng-hong
    Sheng, Rui
    Xie, Hong
    ACTA PHARMACOLOGICA SINICA, 2020, 41 (04): : 535 - 545
  • [24] Baicalin improves podocyte injury in rats with diabetic nephropathy by inhibiting PI3K/Akt/ mTOR signaling pathway
    Ou, Yi
    Zhang, Wenjuan
    Chen, Shaopeng
    Deng, Haihua
    OPEN MEDICINE, 2021, 16 (01): : 1286 - 1298
  • [25] Metformin inhibits the proliferation of canine mammary gland tumor cells through the AMPK/AKT/mTOR signaling pathway in vitro
    Fan, Yuying
    Ren, Xiaoli
    Wang, Yingxue
    Xu, Enshuang
    Wang, Shuang
    Ge, Ruidong
    Liu, Yun
    ONCOLOGY LETTERS, 2021, 22 (06)
  • [26] Glucose activates the primordial follicle through the AMPK/mTOR signaling pathway
    Xu, Shengyu
    Wu, Xiaoling
    Dong, Yanpeng
    Xu, Mengmeng
    Li, Zimei
    Chen, Sirun
    Zhuo, Yong
    Lin, Yan
    Che, Lianqiang
    Fang, Zhengfeng
    Feng, Bin
    Li, Jian
    Wang, Jianping
    Wu, De
    Ren, Zhihua
    CLINICAL AND TRANSLATIONAL MEDICINE, 2020, 10 (03):
  • [27] Rapamycin Upregulates Autophagy by Inhibiting the mTOR-ULK1 Pathway, Resulting in Reduced Podocyte Injury
    Wu, Lingling
    Feng, Zhe
    Cui, Shaoyuan
    Hou, Kai
    Tang, Li
    Zhou, Jianhui
    Cai, Guangyan
    Xie, Yuansheng
    Hong, Quan
    Fu, Bo
    Chen, Xiangmei
    PLOS ONE, 2013, 8 (05):
  • [28] Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy
    Wei Jing Liu
    Zhi-hang Li
    Xiao-cui Chen
    Xiao-lu Zhao
    Zhen Zhong
    Chen Yang
    Hong-luan Wu
    Ning An
    Wei-yan Li
    Hua-feng Liu
    Scientific Reports, 7
  • [29] Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy
    Liu, Wei Jing
    Li, Zhi-hang
    Chen, Xiao-cui
    Zhao, Xiao-lu
    Zhong, Zhen
    Yang, Chen
    Wu, Hong-luan
    An, Ning
    Li, Wei-yan
    Liu, Hua-feng
    SCIENTIFIC REPORTS, 2017, 7
  • [30] Salvianolate Ameliorates Renal Damage Induced by C-BSA in Membranous Nephropathy Rats Through Inhibiting Hypercoagulable State and Alleviating Podocyte Injury
    Chen, Wenjun
    Tan, Jinchuan
    Chen, Suzhi
    Yang, Fengwen
    Yan, Huiming
    Duo, Huiling
    Zhou, Huijie
    PHARMACOGNOSY MAGAZINE, 2023, 19 (03) : 678 - 688
12345