GABA-Nitrergic Interactions in the Nucleus Accumbens during Inhibition of Exploratory Behavior by Danger Signals

被引：0

作者：

Saul’skaya N.B. ^{[1
]}

Terekhova E.A. ^{[1
]}

机构：

[1] Laboratory for the Physiology of Higher Nervous Activity, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

来源：

Neuroscience and Behavioral Physiology | 2015年 / 45卷 / 2期

基金：

俄罗斯基础研究基金会;

关键词：

citrulline; exploratory behavior; fear; GABA[!sub]A[!/sub] receptors; microdialysis; nitric oxide; nucleus accumbens;

D O I：

10.1007/s11055-015-0058-z

中图分类号：

学科分类号：

摘要：

Vital intracerebral microdialysis experiments in Sprague–Dawley rats with high-performance liquid chromatography (HPLC) showed that presentation during exploratory behavior of a tone previously combined with pain stimulation decreased exploratory activity and inhibited the exploratory behavior-induced increase in the extracellular citrulline (a co-product of NO synthesis) level in the medial sector of the nucleus accumbens. Administration of the GABAA receptor antagonist bicuculline (20 μM) into the medial sector of the nucleus accumbens firstly produced partial recovery of the increase in the extracellular citrulline level in this structure induced by exploratory behavior and suppressed by a tone previously combined with pain stimulation and, secondly, prevented inhibition of exploratory behavior by this danger sound signal. The data obtained here provide the first evidence that inhibition of exploratory behavior by danger signals and the exploration-associated activation of the nitrergic system of the medial sector of the nucleus accumbens are mediated by GABAA receptor mechanisms. © 2015, Springer Science+Business Media New York.

引用

页码：199 / 205

页数：6

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