Liver-only metastatic colorectal cancer patients and thymidylate synthase polymorphisms for predicting response to 5-fluorouracil-based chemotherapy

被引：0
作者：
F Graziano
A Ruzzo
F Loupakis
D Santini
V Catalano
E Canestrari
P Maltese
R Bisonni
L Fornaro
G Baldi
G Masi
A Falcone
G Tonini
P Giordani
P Alessandroni
L Giustini
B Vincenzi
M Magnani
机构：
[1] Medical Oncology,
[2] Azienda Ospedaliera ‘Ospedale San Salvatore’,undefined
[3] Institute of Biochemistry ‘G Fornaini’,undefined
[4] University of Urbino,undefined
[5] Medical Oncology,undefined
[6] Hospital of Livorno,undefined
[7] Medical Oncology,undefined
[8] University Campus Biomedico,undefined
[9] Medical Oncology,undefined
[10] Hospital of Fermo,undefined
[11] Medical Oncology,undefined
[12] Hospital of Livorno and University of Pisa,undefined
来源：
British Journal of Cancer | 2008年 / 99卷
关键词：
colorectal cancer; liver metastasis; thymidylate synthase; polymorphisms; 5-fluorouracil; pharmacogenetics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We investigated the association between thymidylate synthase (TS) germline polymorphisms and response to 5-fluorouracil-based chemotherapy in 80 patients with liver-only metastatic colorectal cancer (MCRC). The tandem repeat polymorphism (VNTR) in TS 5′-untranslated region (5′-UTR), which consists of two (2R) or three (3R) 28-bp repeated sequences, with or without a G/C nucleotide change in 3R carriers (3G or 3C) and a 6-bp insertion/deletion (6+/6−) in the TS 3′-UTR, was studied. The distinction between high (2R/3G, 3C/3G and 3G/3G) and low (2R/2R, 2R/3C and 3C/3C) TS expression genotypes according to the 5′-UTR VNTR+G/C nucleotide change showed significant association with tumour response (P=0.01). In particular, high TS expression genotypes were found in 8 out of 34 patients (23.5%) with complete or partial response and in 24 out of 46 patients (52%) with stable disease and disease progression. Liver-only MCRC patients are a homogeneous and clinical relevant subgroup that may represent an ideal setting for studying the actual influence of TS polymorphisms.
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页码：716 / 721
页数：5
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