Human conditions of insulin-like growth factor-I (IGF-I) deficiency

被引：0
作者：
Juan E Puche
Inma Castilla-Cortázar
机构：
[1] Universidad CEU San Pablo,Applied Molecular Medicine Institute (IMMA), School of Medicine, Department of Medical Physiology
来源：
Journal of Translational Medicine | / 10卷
关键词：
Laron syndrome; Liver cirrhosis; Aging; Oxidative stress; GH/IGF-I axis; Mitochondrial dysfunction; Cellular protection; Growth; Cancer protection;
D O I：
暂无
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摘要：
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).
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