Clinical, endoscopic and pathologic spectrum of non-steroidal anti-inflammatory drug-induced colitis

被引：10

作者：

Geramizadeh B. ^{[1
]}

Taghavi A. ^{[1
]}

Banan B. ^{[1
]}

机构：

[1] Pathology Department, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz

来源：

Indian Journal of Gastroenterology | 2009年 / 28卷 / 4期

关键词：

Colitis; NSAID;

D O I：

10.1007/s12664-009-0053-9

中图分类号：

学科分类号：

摘要：

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for treatment of arthritis and many other painful conditions. These drugs may cause damage not only to the upper gastrointestinal tract but also to the small and large intestine. This prospective study aimed to determine the presence of colonic lesions among 24 patients who were receiving NSAIDs for more than 3 months, and presented with diarrhea, intractable abdominal pain, and lower GI bleeding. Colonoscopy was done and multiple biopsies from different sites in the colon were obtained. Colonoscopy was normal in 11 (45.8%), showed inflammation or superficial ulcers in 7 (29.1%) and solitary or multiple deep ulcers in 6 (25%). Histology showed erosions in 12 (50%) and lymphocytic colitis in 9 (37.5%); histology was normal in 4 (16.6%). NSAID-induced colonic damage may have clinically significant sequel. © Indian Society of Gastroenterology 2009.

引用

页码：150 / 153

页数：3

共 15 条

[1]

Fries J.F., Williams C.A., Bloch D.A., The relative toxicity of nonsteroidal anti-inflammatory drugs, Arthritis Rheum, 34, pp. 1353-1357, (1991)

[2]

Allison M.C., Howatson A.G., Torrance C.J., Lee F.D., Russell R.I., Gastrointestinal damage associated with the use of nonsteroidal anti-inflammatory drugs, N Engl J Med, 327, pp. 749-754, (1992)

[3]

Aabakken L., Non-steroidal, anti-inflammatory drugs-the extending scope of gastrointestinal side effects, Aliment Pharmacol Ther, 6, pp. 143-162, (1992)

[4]

Chatelain D., Mokrani N., Flejou J.F., Microscopic colitis: Collagenous colitis and lymphocytic colitis, Ann Pathol, 27, pp. 448-458, (2007)

[5]

Katsinelos P., Christodoulo K., Pilpilidis I., Et al., Colopathy associated with the systemic use of nonsteroidal anti-inflammatory medications. An underestimated entity, Hepatogastroenterology, 49, pp. 345-348, (2002)

[6]

Larkai E.N., Smith J.L., Lidsky M.D., Graham D.Y., Gastroduodenal mucosa and dyspeptic symptoms in arthritic patents during chronic nonsteroidal anti-inflammatory drug use, Am J Gastroenterol, 82, pp. 1153-1158, (1987)

[7]

Bjarnason I., Hayllar J., Macpherson A.J., Russell A.S., Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans, Gastroenterology, 104, pp. 1832-1847, (1993)

[8]

Hoftiezer J.W., Silvoso G.R., Burks M., Ivy K.J., Comparison of the effect of regular and enteric-coated aspirin on gastroduodenal mucosa of man, Lancet, 2, pp. 609-612, (1980)

[9]

Trondstad R.I., Aadland E., Holler T., Olassen B., Gastroscopic findings after treatment with enteric-coated and plain naproxen tablets in healthy subjects, Scand J Gastroenterol, 20, pp. 239-242, (1985)

[10]

Byrne M.F., McGuinness J., Smyth C.M., Et al., Nonsteroidal anti-inflammatory drug-induced diaphragms and ulceration in the colon, Eur J Gastroenterol Hepatol, 14, pp. 1265-1269, (2002)

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