Granulomatous vasculitides and vasculitides with extravascular granulomatosis

被引：4

作者：

Arnold, Sabrina ^{[1
]}

Klapa, Sebastian ^{[1
]}

Holl-Ulrich, Konstanze ^{[2
]}

Mueller, Antje ^{[3
]}

Kerstein-Staehle, Anja ^{[3
]}

Lamprecht, Peter ^{[1
]}

机构：

[1] Univ Lubeck, Klin Rheumatol & Klin Immunol, Ratzeburger Allee 160, D-23538 Lubeck, Germany

[2] MVZ Lab Lademannbogen GmbH, Pathol Hamburg, Hamburg, Germany

[3] Univ Lubeck, Forschungslab, Klin Rheumatol & Klin Immunol, Lubeck, Germany

来源：

ZEITSCHRIFT FUR RHEUMATOLOGIE | 2022年 / 81卷 / 07期

关键词：

Granulomatosis with polyangiitis; Eosinophilic granulomatosis with polyangiitis; Giant cell arteritis; Takayasu arteritis; Granuloma; EOSINOPHILIC GRANULOMATOSIS; ARTERITIS; CELLS;

D O I：

10.1007/s00393-022-01249-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Vasculitides are inflammatory diseases of blood vessels caused by autoimmune or infectious processes, which are associated with alterations and destruction of the vascular wall. From a histopathological point of view, granulomatous vasculitides can be distinguished from necrotizing vasculitides with respect to the pattern of inflammation. Granulomatous vasculitides are characterized by intramural, predominantly lymphohistiocytic infiltrates with the formation of giant cells. They include giant cell arteritis (GCA) and Takayasu arteritis (TAK). By contrast, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) belongs to the group of necrotizing vasculitides. AAV includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). In addition to systemic necrotizing small vessel vasculitis, GPA and EGPA are characterized by extravascular granulomatous necrotizing inflammation mainly affecting the upper and/or lower respiratory tract, in EGPA with eosinophilic infiltrates. These granulomatous lesions are part of the autoimmune process and associated with tissue damage.

引用

页码：558 / 566

页数：9

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