The genetics of juvenile idiopathic arthriti what is new in 2010?

被引：23
作者：
Angeles-Han S. [1 ]
Prahalad S. [2 ]
机构：
[1] Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
[2] Departments of Pediatrics and Human Genetics, Emory University School of Medicine, Atlanta, GA 30322
来源：
Current Rheumatology Reports | 2010年 / 12卷 / 2期
关键词：
Association; Autoimmune; Genetics; Juvenile idiopathic arthritis; Juvenile rheumatoid arthritis;
D O I：
10.1007/s11926-010-0087-0
中图分类号：
学科分类号：
摘要：
Juvenile idiopathic arthritis (JIA), the most common cause of chronic arthritis in children, is believed to be influenced by genetic factors. Recent studies on the genetics of JIA have not only validated proposed genetic associations but have also led to the recognition of novel genetic associations. Studies of specific genes have been modeled on the premise of shared autoimmunity, wherein genetic variants that predispose to other autoimmune phenotypes may also confer susceptibility to JIA. The advent of genome-wide association studies has accelerated the detection of non-HLA susceptibility loci in other autoimmune phenotypes and is likely to uncover novel JIA-associated variants as well. This review highlights recent genetic investigations of JIA. © Springer Science+Business Media, LLC 2010.
引用
收藏
页码：87 / 93
页数：6
相关论文
共 51 条
  • [1] Ravelli A., Martini A., Juvenile idiopathic arthritis, Lancet, 369, pp. 767-778, (2007)
  • [2] Petty R.E., Southwood T.R., Manners P., Et al., International league of associations for rheumatology classification of juvenile idiopathic arthritis: Second revision, edmonton, 2001, J Rheumatol, 31, pp. 390-392, (2004)
  • [3] Clemens L.E., Albert E., Ansell B.M., Sibling pairs affected by chronic arthritis of childhood: Evidence for a genetic predisposition, J Rheumatol, 12, pp. 108-113, (1985)
  • [4] Moroldo M.B., Tague B.L., Shear E.S., Et al., Juvenile rheumatoid arthritis in affected sibpairs, Arthritis Rheum, 40, pp. 1962-1966, (1997)
  • [5] Prahalad S., Genetic analysis of juvenile rheumatoid arthritis: Approaches to complex traits, Curr Probl Pediatr Adolesc Health Care, 36, pp. 83-90, (2006)
  • [6] Glass D.N., Giannini E.H., Juvenile rheumatoid arthritis as a complex genetic trait, Arthritis Rheum, 42, pp. 2261-2268, (1999)
  • [7] Prahalad S., Glass D.N., A comprehensive review of the genetics of juvenile idiopathic arthritis, Pediatr Rheumatol Online J, 6, (2008)
  • [8] Plenge R.M., Rheumatoid arthritis genetics: 2009 update, Curr Rheumatol Rep, 11, pp. 351-356, (2009)
  • [9] Prahalad S., Ryan M.H., Shear E.S., Et al., Juvenile rheumatoid arthritis: Linkage to HLA demonstrated by allele sharing in affected sibpairs, Arthritis Rheum, 43, pp. 2335-2338, (2000)
  • [10] Prahalad S., Genetics of juvenile idiopathic arthritis: An update, Current Opinion in Rheumatology, 16, 5, pp. 588-594, (2004)
123456