N-Adamantyl-4-Methylthiazol-2-Amine Attenuates Glutamate-Induced Oxidative Stress and Inflammation in the Brain

被引：0
作者：
Seung-Ju Yang
Eun-A Kim
Min-Jun Chang
Jiae Kim
Jung-Min Na
Soo Young Choi
Sung-Woo Cho
机构：
[1] Konyang University,Department of Biomedical Laboratory Science
[2] University of Ulsan College of Medicine,Department of Biochemistry and Molecular Biology
[3] Sema High School,Department of Biomedical Science and Research Institute for Bioscience and Biotechnology
[4] Hallym University,undefined
来源：
Neurotoxicity Research | 2017年 / 32卷
关键词：
Glutamate; -Adamantyl-4-methylthiazol-2-amine; Oxidative stress; Neuroinflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, we explored the possible mechanisms underlying the neuroprotective and anti-oxidative effects of N-adamantyl-4-methylthiazol-2-amine (KHG26693) against in vivo glutamate-induced toxicity in the rat cerebral cortex. Our results showed that pretreatment with KHG26693 significantly attenuated glutamate-induced elevation of lipid peroxidation, tumor necrosis factor-α, interferon gamma, IFN-γ, interleukin-1β, nitric oxide, reactive oxygen species, NADPH oxidase, caspase-3, calpain activity, and Bax. Furthermore, KHG26693 pretreatment attenuated key antioxidant parameters such as levels of superoxide dismutase, catalase, glutathione, and glutathione reductase. KHG26693 also attenuated the protein levels of inducible nitric oxide synthase, neuronal nitric oxide synthase, nuclear factor erythroid 2-related factor 2, heme oxygenase-1, and glutamate cysteine ligase catalytic subunit caused by glutamate toxicity. Finally, KHG26693 mitigated glutamate-induced changes in mitochondrial ATP level and cytochrome oxidase c. Thus, KHG26693 functions as neuroprotective and anti-oxidative agent against glutamate-induced toxicity through its antioxidant and anti-inflammatory activities in rat brain at least in part.
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页码：107 / 120
页数：13
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