D-amino acid oxidase: structure, catalytic mechanism, and practical application

被引：0
|
作者：
V. I. Tishkov
S. V. Khoronenkova
机构：
[1] Lomonosov Moscow State University,Department of Chemical Enzymology, Faculty of Chemistry
来源：
Biochemistry (Moscow) | 2005年 / 70卷
关键词：
D-amino acid oxidase; cloning; expression; stability; protein engineering;
D O I：
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学科分类号：
摘要：
D-Amino acid oxidase (DAAO) is a FAD-dependent enzyme that plays an important role in microbial metabolism, utilization of endogenous D-amino acids, regulation of the nervous system, and aging in mammals. DAAO from yeasts Rhodotorula gracilis and Trigonopsis variabilis are used to convert cephalosporin C into 7-aminocephalosporanic acid, the precursor of other semi-synthetic cephalosporins. This review summarizes the recent data on the enzyme localization, physiological role, gene cloning and expression, and the studies on the enzyme structure, stability, catalytic mechanism, and practical applications.
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页码：40 / 54
页数：14
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