New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development

被引：0
作者：
Yosuke Kurashima
Hiroshi Kiyono
机构：
[1] Institute of Medical Science,Division of Mucosal Immunology, Department of Microbiology and Immunology
[2] University of Tokyo,Division of Infectious Genetics, Department of Microbiology and Immunology
[3] Core Research for Evolutional Science and Technology (CREST),Department of Medical Genome Science
[4] Japan Science and Technology Agency (JST),undefined
[5] Institute of Medical Science,undefined
[6] University of Tokyo,undefined
[7] Graduate School of Frontier Science,undefined
[8] University of Tokyo,undefined
[9] International Research and Development Center for Mucosal Vaccines,undefined
[10] Institute of Medical Science,undefined
[11] University of Tokyo,undefined
来源：
Experimental & Molecular Medicine | 2014年 / 46卷
关键词：
food allergy; intestinal inflammation; mucosal mast cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
To achieve immune homeostasis in such a harsh environment as the intestinal mucosa, both active and quiescent immunity operate simultaneously. Disruption of gut immune homeostasis leads to the development of intestinal immune diseases such as colitis and food allergies. Among various intestinal innate immune cells, mast cells (MCs) play critical roles in protective immunity against pathogenic microorganisms, especially at mucosal sites. This suggests the potential for a novel MC-targeting type of vaccine adjuvant. Dysregulated activation of MCs also results in inflammatory responses in mucosal compartments. The regulation of this yin and yang function of MCs remains to be elucidated. In this review, we focus on the roles of mucosal MCs in the regulation of intestinal allergic reaction, inflammation and their potential as a new target for the development of mucosal adjuvants.
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页码：e83 / e83
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  • [1] Gallo RL(2012)Epithelial antimicrobial defence of the skin and intestine Nat Rev Immunol 12 503-516
  • [2] Hooper LV(2007)Human mast cells, bacteria, and intestinal immunity Immunol Rev 217 329-337
  • [3] Bischoff SC(2012)Innate lymphoid cells: balancing immunity, inflammation, and tissue repair in the intestine Cell Host Microbe 12 445-457
  • [4] Kramer S(2010)Mast cell mediators in tolerance Curr Opin Immunol 22 643-648
  • [5] Tait Wojno ED(2011)Mast cells as regulators of skin inflammation and immunity Acta Derm Venereol 91 644-650
  • [6] Artis D(2005)Mast cells as “tunable” effector and immunoregulatory cells: recent advances Annu Rev Immunol 23 749-786
  • [7] de Vries VC(2013)Protective and pathological roles of mast cells and basophils Nat Rev Immunol 13 362-375
  • [8] Noelle RJ(2012)Developmental origin and functional specialization of mast cell subsets Immunity 37 25-33
  • [9] Harvima IT(2011)Mast cell proteases as protective and inflammatory mediators Adv Exp Med Biol 716 212-234
  • [10] Nilsson G(2000)Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1 J Exp Med 192 1849-1856
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