Heart-brain interactions in mental stress-induced myocardial ischemia

被引：2
作者：
Soufer R. [1 ]
Jain H. [1 ]
Yoon A.J. [1 ]
机构：
[1] VA Connecticut Healthcare System, Yale University School of Medicine, West Haven, CT 06516
来源：
Current Cardiology Reports | 2009年 / 11卷 / 2期
关键词：
Heart Rate Variability; Myocardial Ischemia; Nuclear Cardiology; Mental Stress; Parasympathetic Tone;
D O I：
10.1007/s11886-009-0020-1
中图分类号：
学科分类号：
摘要：
Myocardial ischemia that results from emotional provocation occurs in as many as 30% to 50% of patients with coronary artery disease during the discourse of their lives. This emotionally provoked or mental stress ischemia is associated with poor prognosis, with emerging treatment strategies. This article outlines the conceptual constructs that support the pathophysiologic underpinnings, and biobehavioral aspects associated with this mental stress ischemia. We review a biobehavioral model in which cognitive stress is transduced in the brain. The response of the brain to psychosocial stress is a highly sophisticated and integrated process by which sensory inputs are evaluated and appraised for their importance in relation to previous experience and current goals. The biologic consequences of such stress transduced in the central nervous system has its effect on cardiovascular flow and function through changes in autonomic balance, which result in various biologic processes that culminate in the perturbation of flow and function of the heart. © Current Medicine Group, LLC 2009.
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页码：133 / 140
页数：7
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