Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells

被引：0
|
作者：
Sarah Ali Azouaou
Fathi Emhemmed
Noureddine Idris-Khodja
Annelise Lobstein
Valérie Schini-Kerth
Christian D. Muller
Guy Fuhrmann
机构：
[1] Université de Strasbourg,UMR 7213 CNRS, Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie
[2] Université de Strasbourg,UMR 7200 CNRS, Laboratoire d’Innovation Thérapeutique, Faculté de Pharmacie
[3] McGill University,Lady Davis Institute for Medical Research, Sir Mortimer B. Davis
来源：
Investigational New Drugs | 2015年 / 33卷
关键词：
Cancer stem-like cells; Rooperol; Apoptosis; Reactive oxygen species; p53; Oct4;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cancer stem cells (CSCs) are potential targets for innovative anticancer therapies that involve natural products with potential chemopreventive effects. We therefore analyzed the antineoplastic activity of rooperol, the aglycone of the plant-derived compound hypoxoside, on a model of Oct4-expressing cancer stem-like cell, i.e. the human embryonal carcinoma (EC) cell NT2/D1.
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页码：64 / 74
页数：10
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