Study of apolipoproteinc3 Sstl polymorphism in healthy volunteers from Northern India

被引：2

作者：

S. Chhabra

D. P. Agarwal

S. Vasisht

K. Luthra

R. Narang

S. C. Manchanda

L. M. Srivastava

N. Das

机构：

[1] Department of Biochemistry, All India Inst. of Medical Sciences, New Delhi

[2] Department of Cardiology, All India Inst. of Medical Sciences, New Delhi

[3] Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi

[4] Department of Biochemistry, All India Inst. of Medical Sciences, New Delhi-110029, Ansari Nagar

来源：

Indian Journal of Clinical Biochemistry | 2003年 / 18卷 / 2期

关键词：

APOC3; CAD; Hypertriglyceridemia; India; Sstl polymorphism;

D O I：

10.1007/BF02867365

中图分类号：

学科分类号：

摘要：

Several studies including a small case-control (hypertriglyceridemic/normotriglyceridemic individuals) study by us revealed close association between rare S2 allele of APOC3 Sstl polymorphism and hypertriglyceridemia. With the understanding that Asian Indians are highly vulnerable to the adverse effects of hypertriglyceridemia, we extended the investigation and studied the frequency distribution of this polymorphism in 216 healthy volunteers from Northern plains of India. We found that more than 50% of the study population had one or two S2 allele. This may suggest that a larger fraction of this population is genetically predisposed to hypertriglyceridemia.

引用

页码：34 / 38

页数：4

共 30 条

[1]

Jong M.C., Hofker M.H., Havekes L.M., Role of ApoCs in lipoprotein metabolism functional differences between ApoC1, ApoC2, and ApoC3, Arterioscler. Thromb. Vasc. Biol., 19, pp. 472-484, (1999)

[2]

Paul-Hayase H., Rosseneu M., Robinson D., Van Bervliet J.P., Deslypere J.P., Humphries S.E., Polymorphisms in the apolipoprotein (apo) AI-CIII-AIV gene cluster: Detection of genetic variation determining plasma apo Al, apo CIII and apo AIV concentrations, Hum. Genet., 88, pp. 439-446, (1992)

[3]

Rees A., Shoulders C.C., Stocks J., Galton D.J., Baralle F.E., DNA polymorphism adjacent to human apolipoprotein A-1 gene: Relation to hypertriglyceridemia, Lancet, 1, pp. 444-446, (1983)

[4]

Ko Y.L., Ko Y.S., Wu S.M., Teng M.S., Chen F.R., Hsu T.S., Chiang C.W., Lee Y.S., Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese, Hum. Genet., 100, pp. 327-333, (1997)

[5]

Ahn Y.I., Valdez R., Reddy A.P., Cole S.A., Weiss K.M., Ferrell R.E., DNA polymorphisms of the apolipoprotein AI/CIII/AIV gene cluster influences plasma cholesterol and triglyceride levels in the Mayans of the Yucatan peninsula, Mexico, Hum. Hered., 41, pp. 281-289, (1991)

[6]

Zeng Q., Dammerman M., Takada Y., Matsunaga A., Breslow J.L., Sasaki J., An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population, Hum. Genet., 95, pp. 371-375, (1995)

[7]

Bai H., Saku K., Liu R., Imamura M., Arakawa K., Association between coronary heart disease and the apolipoprotein A-I/C-III/A-IV complex in a Japanese population, Hum. Genet., 95, pp. 102-104, (1995)

[8]

Rees A., Stocks J., Paul H., Ohuchi Y., Galton D., Haplotypes identified by DNA polymorphisms at the apolipoprotein A-I and C-III loci and hypertriglyceridemia: A study in a Japanese population, Hum. Genet., 72, pp. 168-171, (1986)

[9]

Hong S.H., Park W.H., Lee C.C., Hong J.H., Kim J.Q., Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects, Clin. Chem., 43, pp. 13-17, (1997)

[10]

Wu J.H., Kao J.T., Wen M.S., Lo S.K., DNA polymorphisms at the apolipoprotein A1-CIII loci in Taiwanese: Correlation of plasma APOCIII with triglyceride level and body mass index, J. Formos. Med. Assoc., 99, pp. 367-374, (2000)

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