Medical devices on chips

被引:0
|
作者
Allan Guan
Parisa Hamilton
Yi Wang
Maud Gorbet
Zhenyu Li
K. Scott Phillips
机构
[1] United States Food and Drug Administration,Division of Biology
[2] Office of Medical Products and Tobacco,Department of Systems Design Engineering
[3] Center for Devices and Radiological Health,Department of Biomedical Engineering
[4] Office of Science and Engineering Laboratories,undefined
[5] Chemistry and Materials Science,undefined
[6] University of Waterloo,undefined
[7] The George Washington University,undefined
[8] Science and Engineering Hall,undefined
来源
Nature Biomedical Engineering | / 1卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The development of medical-device technology is constrained by the financial and ethical considerations of animal testing and clinical trials. Organ-on-a-chip systems are being developed to speed up drug development, yet there has been little recognition or support for the use of this technology in the development and testing of medical devices. In this Perspective, we introduce the concept of medical-device-on-a-chip (MDoC), highlight possible applications and discuss the potential of microfluidic high-throughput technologies for achieving significant time and cost savings over conventional testing. Rather than testing an entire macroscale device, a MDoC has the ability to recapitulate biological function in a physiome associated with medical-device use and to test interactions with device components. In the clinic, MDoCs could also incorporate individual human samples for personalized diagnostics. We also review research towards the integration of key elements of organ-on-a-chip technologies with medical-device testing.
引用
收藏
相关论文
共 50 条
  • [21] Modeling of CMOS Devices and Circuits on Flexible Ultrathin Chips
    Vilouras, Anastasios
    Heidari, Hadi
    Gupta, Shoubhik
    Dahiya, Ravinder
    IEEE TRANSACTIONS ON ELECTRON DEVICES, 2017, 64 (05) : 2038 - 2046
  • [22] Biomedical Devices for Pathogen Detection Using Microfluidic Chips
    Lin, Yung-Sheng
    Ming-Yuan-Lee
    Yang, Chih-Hui
    Huang, Keng-Shiang
    CURRENT PROTEOMICS, 2014, 11 (02) : 116 - 120
  • [23] New Developments in Mobile Devices chips and receivers for GNSS
    Mattos, Philip G.
    PROCEEDINGS OF THE 26TH INTERNATIONAL TECHNICAL MEETING OF THE SATELLITE DIVISION OF THE INSTITUTE OF NAVIGATION (ION GNSS 2013), 2013, : 1702 - 1716
  • [24] ESD Effect Test Research on Electronic Devices and Chips
    Jie, Yang
    Proceedings of the 6th International Conference on Applied Electrostatics, 2008, : 318 - 320
  • [25] ELECTRONIC AND IONIC DEVICES: Semiconductor Chips with Brain Tissue
    Fromherz, Peter
    IEEE INTERNATIONAL ELECTRON DEVICES MEETING 2008, TECHNICAL DIGEST, 2008, : 3 - 10
  • [26] Contraceptive devices and the Medical Devices Directive
    Austin, A
    BRITISH JOURNAL OF FAMILY PLANNING, 2000, 26 (01): : 56 - 56
  • [27] Medical batteries for external medical devices
    Passerini, S
    Owens, BB
    JOURNAL OF POWER SOURCES, 2001, 97-8 : 750 - 754
  • [28] Advances in Medical Devices and Medical Electronics
    Neuman, Michael R.
    Baura, Gail D.
    Meldrum, Stuart
    Soykan, Orhan
    Valentinuzzi, Max E.
    Leder, Ron S.
    Micera, Silvestro
    Zhang, Yuan-Ting
    PROCEEDINGS OF THE IEEE, 2012, 100 : 1537 - 1550
  • [29] Usability for medical devices
    Braun, S
    2005 IEEE Symposium on Product Safety Engineering (PSES), 2005, : 16 - 22
  • [30] Immunotoxicity of medical devices
    Rodgers, K
    Klykken, P
    Jacobs, J
    Frondoza, C
    Tomazic, V
    Zelikoff, J
    FUNDAMENTAL AND APPLIED TOXICOLOGY, 1997, 36 (01): : 1 - 14