The emerging role of WISP proteins in tumorigenesis and cancer therapy

被引：0
作者：
Yi Liu
Yizuo Song
Miaomiao Ye
Xiaoli Hu
Z. Peter Wang
Xueqiong Zhu
机构：
[1] The Second Affiliated Hospital of Wenzhou Medical University,Department of Obstetrics and Gynecology
[2] The Second Affiliated Hospital of Wenzhou Medical University,Center of Scientific Research
[3] Bengbu Medical College,Department of Biochemistry and Molecular Biology, School of Laboratory Medicine
[4] Beth Israel Deaconess Medical Center,Department of Pathology
[5] Harvard Medical School,undefined
来源：
Journal of Translational Medicine | / 17卷
关键词：
Cancer; WISP; Oncogene; Drug; Targets; Therapy;
D O I：
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中图分类号：
学科分类号：
摘要：
Accumulated evidence has demonstrated that WNT1 inducible signaling pathway protein (WISP) genes, which belong to members of the CCN growth factor family, play a pivotal role in tumorigenesis and progression of a broad spectrum of human cancers. Mounting studies have identified that WISP proteins (WISP1-3) exert different biological functions in various human malignancies. Emerging evidence indicates that WISP proteins are critically involved in cell proliferation, apoptosis, invasion and metastasis in cancers. Because the understanding of a direct function of WISP proteins in cancer development and progression has begun to emerge, in this review article, we describe the physiological function of WISP proteins in a variety of human cancers. Moreover, we highlight the current understanding of how the WISP protein is involved in tumorigenesis and cancer progression. Furthermore, we discuss that targeting WISP proteins could be a promising strategy for the treatment of human cancers. Hence, the regulation of WISP proteins could improve treatments for cancer patients.
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