Carcinoid valve disease

被引：23
作者：
Askew J.W. [1 ]
Connolly H.M. [1 ]
机构：
[1] Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, Gonda 6
来源：
Current Treatment Options in Cardiovascular Medicine | 2013年 / 15卷 / 5期
关键词：
Carcinoid; Carcinoid heart disease; Carcinoid syndrome; Carcinoid tumors; Carcinoid valve disease; Pulmonary regurgitation; Pulmonary stenosis; Serotonin; Somatostatin; Tricuspid regurgitation; Valve surgery; Valves; Valvular heart disease;
D O I：
10.1007/s11936-013-0265-2
中图分类号：
学科分类号：
摘要：
Opinion statement: Carcinoid is a rare neuroendocrine tumor that typically originates in the gastrointestinal tract and can result in a constellation of symptoms, mediated by vasoactive substances, referred to as carcinoid syndrome. Carcinoid valve and heart disease is characterized by the plaque-like, endocardial fibrous tissue deposits, primarily affecting the right heart endocardium and valves, which result as a consequence of the disease process. Potential mechanisms for the carcinoid valve disease include the complex role of excess serotonin and its interaction with serotonin receptors and transporters. Carcinoid valve and heart disease is a frequent occurrence in patients with carcinoid syndrome and is accountable for substantial morbidity and mortality. Cardiac surgery remains the most effective treatment option for carcinoid valve disease and a multidisciplinary approach at an experienced center is recommended for patients with metastatic carcinoid and carcinoid heart disease. © 2013 Springer Science+Business Media New York.
引用
收藏
页码：544 / 555
页数：11
相关论文
共 57 条
  • [11] Pandya U.H., Pellikka P.A., Enriquez-Sarano M., Et al., Metastatic carcinoid tumor to the heart: Echocardiographic-pathologic study of 11 patients, J Am Coll Cardiol, 40, pp. 1328-1332, (2002)
  • [12] Ferrans V.J., Roberts W.C., The carcinoid endocardial plaque: An ultrastructural study, Hum Pathol, 7, pp. 387-409, (1976)
  • [13] Bernheim A.M., Connolly H.M., Hobday T.J., Et al., Carcinoid heart disease, Prog Cardiovasc Dis, 49, pp. 439-451, (2007)
  • [14] Simula D.V., Edwards W.D., Tazelaar H.D., Et al., Surgical pathology of carcinoid heart disease: A study of 139 valves from 75 patients spanning 20 years, Mayo Clinic Proc., 77, pp. 139-147, (2002)
  • [15] Bhattacharyya S., Schapira A.H., Mikhailidis D.P., Et al., Drug-induced fibrotic valvular heart disease, Lancet, 374, pp. 577-585, (2009)
  • [16] Rothman R.B., Baumann M.H., Savage J.E., Et al., Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications, Circulation, 102, pp. 2836-2841, (2000)
  • [17] Sareyyupoglu B., Connolly H.M., Schaff H.V., Surgical excision of right ventricular carcinoid tumor in a symptomatic patient without carcinoid valve disease, J Thorac Cardiovasc Surg, 140, pp. 23-25, (2010)
  • [18] Melmon K.L., Sjoerdsma A., Mason D.T., Distinctive clinical and therapeutic aspects of the syndrome associated with bronchial carcinoid tumors, Am J Med, 39, pp. 568-581, (1965)
  • [19] Feldman J.M., Lee E.M., Serotonin content of foods: Effect on urinary excretion of 5-hydroxyindoleacetic acid, Am J Clin Nutr, 42, pp. 639-643, (1985)
  • [20] Richter G., Stockmann F., Conlon J.M., Et al., Serotonin release into blood after food and pentagastrin. Studies in healthy subjects and in patients with metastatic carcinoid tumors, Gastroenterology, 91, pp. 612-618, (1986)
123456