Carcinoid valve disease

被引：23
作者：
Askew J.W. [1 ]
Connolly H.M. [1 ]
机构：
[1] Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, Gonda 6
来源：
Current Treatment Options in Cardiovascular Medicine | 2013年 / 15卷 / 5期
关键词：
Carcinoid; Carcinoid heart disease; Carcinoid syndrome; Carcinoid tumors; Carcinoid valve disease; Pulmonary regurgitation; Pulmonary stenosis; Serotonin; Somatostatin; Tricuspid regurgitation; Valve surgery; Valves; Valvular heart disease;
D O I：
10.1007/s11936-013-0265-2
中图分类号：
学科分类号：
摘要：
Opinion statement: Carcinoid is a rare neuroendocrine tumor that typically originates in the gastrointestinal tract and can result in a constellation of symptoms, mediated by vasoactive substances, referred to as carcinoid syndrome. Carcinoid valve and heart disease is characterized by the plaque-like, endocardial fibrous tissue deposits, primarily affecting the right heart endocardium and valves, which result as a consequence of the disease process. Potential mechanisms for the carcinoid valve disease include the complex role of excess serotonin and its interaction with serotonin receptors and transporters. Carcinoid valve and heart disease is a frequent occurrence in patients with carcinoid syndrome and is accountable for substantial morbidity and mortality. Cardiac surgery remains the most effective treatment option for carcinoid valve disease and a multidisciplinary approach at an experienced center is recommended for patients with metastatic carcinoid and carcinoid heart disease. © 2013 Springer Science+Business Media New York.
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页码：544 / 555
页数：11
相关论文
共 57 条
  • [1] Modlin I.M., Sandor A., An analysis of 8305 cases of carcinoid tumors, Cancer, 79, pp. 813-829, (1997)
  • [2] Pellikka P.A., Tajik A.J., Khandheria B.K., Et al., Carcinoid heart disease. Clinical and echocardiographic spectrum in 74 patients, Circulation, 87, pp. 1188-1196, (1993)
  • [3] Lundin L., Norheim I., Landelius J., Et al., Carcinoid heart disease: Relationship of circulating vasoactive substances to ultrasound-detectable cardiac abnormalities, Circulation, 77, pp. 264-269, (1988)
  • [4] Anderson A.S., Krauss D., Lang R., Cardiovascular complications of malignant carcinoid disease, Am Heart J., 134, pp. 693-702, (1997)
  • [5] Bhattacharyya S., Toumpanakis C., Caplin M.E., Et al., Analysis of 150 patients with carcinoid syndrome seen in a single year at one institution in the first decade of the twenty-first century, Am J Cardiol, 101, pp. 378-381, (2008)
  • [6] Palaniswamy C., Frishman W.H., Aronow W.S., Carcinoid heart disease, Cardiol Rev, 20, pp. 167-176, (2012)
  • [7] Chaowalit N., Connolly H.M., Schaff H.V., Et al., Carcinoid heart disease associated with primary ovarian carcinoid tumor, Am J Cardiol, 93, pp. 1314-1315, (2004)
  • [8] Wilkowske M.A., Hartmann L.C., Mullany C.J., Et al., Progressive carcinoid heart disease after resection of primary ovarian carcinoid, Cancer, 73, pp. 1889-1891, (1994)
  • [9] Bernheim A.M., Connolly H.M., Pellikka P.A., Carcinoid heart disease in patients without hepatic metastases, Am J Cardiol, 99, pp. 292-294, (2007)
  • [10] Roberts W.C., A unique heart disease associated with a unique cancer: Carcinoid heart disease, Am J Cardiol, 80, pp. 251-256, (1997)
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