Clinical relevance of circulating cell-free microRNAs in cancer

被引：0

作者：

Heidi Schwarzenbach

Naohiro Nishida

George A. Calin

Klaus Pantel

机构：

[1] Centre of Experimental Medicine,Department of Tumour Biology

[2] University Cancer Centre,Department of Experimental Therapeutics and the Centre for RNA Interference and Non

[3] University Medical Centre Hamburg-Eppendorf,Coding RNAs

[4] The University of Texas,undefined

[5] MD Anderson Cancer Center,undefined

来源：

Nature Reviews Clinical Oncology | 2014年 / 11卷

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学科分类号：

摘要：

Alterations in microRNAs (miRNAs) are involved in the pathogenesis of various types of human cancers, and because of the stability of tumour-derived cell-free microRNAs, these show potential as novel biomarkersCell-free miRNAs can be detected not only in plasma and serum, but also in other body fluids, such as urine and saliva, and serve as a non-invasive diagnostic toolmiRNAs also have an important role in chemo-resistance of cancer cells, and could be useful predictors of therapeutic responseMethods of detection, such as microarray analysis and deep-sequencing, enable a comprehensive profiling of cell-free miRNAs (including various isoforms) from low amounts of RNA samples

引用

页码：145 / 156

页数：11

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