Genetic engineering of mammals

被引:0
作者
Kevin D. Wells
机构
[1] University of Missouri,Division of Animal Sciences, Animal Sciences Research Center
来源
Cell and Tissue Research | 2016年 / 363卷
关键词
Transgenesis; Knockout; Genetic engineering; Biomedical models; Alternative models;
D O I
暂无
中图分类号
学科分类号
摘要
Historically, genetic engineering for mammalian reproductive questions has been accomplished primarily in the mouse. However, all the genetic manipulations that can be done in the mouse can now be accomplished in most domesticated mammals. Random integration of transgenes, homologous recombination and gene editing are now routine for several mammalian species. For livestock, queries related to fertility can be asked directly for the species in question, without a need for a mouse model. For human clinical concerns, the most appropriate model should be selected based on physiology, anatomy, or even size. The mouse will continue to be a useful genetically engineered model. However, other species are now amenable to the full range of genetic manipulations and should be considered as possible models for human conditions when appropriate.
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页码:289 / 294
页数:5
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