Influence of substituent effects on spectroscopic properties and antimicrobial activity of 5-(4′-substituted phenylazo)-2-thioxothiazolidinone derivatives

被引：0
作者：
M. I. Abou-Dobara
A. Z. El-Sonbati
Sh. M. Morgan
机构：
[1] Damietta University,Botany Department, Faculty of Science
[2] Damietta University,Chemistry Department, Faculty of Science
来源：
World Journal of Microbiology and Biotechnology | 2013年 / 29卷
关键词：
Azo rhodamine derivatives; Antibacterial and antifungal activities;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
5-(4′-substituted phenylazo)-2-thioxothiazolidinone derivatives (HLn) have been synthesized and characterized by elemental analysis, spectra (IR, electronic and 1H NMR). The IR spectral data indicate that the compounds can exist in two resonance structures. The synthesized ligands were screened for their antimicrobial activity against four bacterial species, two Gram positive bacteria (Bacillus cereus and Staphylococcus aureus) and two Gram negative bacteria (Escherichia coli and Klebsiella pneumoniae) as well as against some species various of fungi; Aspergillus niger, Penicillium chrysogenum, Penicilliumitalicum and Fusarium oxysporium. The results showed that most these ligands are good antibacterial agents against B. cereus and S. aureus and antifungal agents against A. niger and F. oxysporium. HL3 was found to be the most effect compound against all tested microorganisms. The size of clear zone were ordered as follows p-(OCH3 < CH3 < H < Cl < NO2) as expected from Hammett’s constant σR.
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页码：119 / 126
页数：7
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