The relation of p53 gene mutations to gastric cancer subsite and phenotype

被引:0
作者
D. Tolbert
C. Fenoglio-Preiser
A. Noffsinger
G. De Voe
J. MacDonald
J. Benedetti
G.N. Stemmermann
机构
[1] University of Cincinnati School of Medicine,Department of Pathology and Laboratory Medicine
[2] St Vincents Hospital,Cancer Center
[3] Southwest Oncology Group,Statistical Office
[4] University of Washington,undefined
来源
Cancer Causes & Control | 1999年 / 10卷
关键词
cardioesophageal cancer; gastric cancer; p53 mutations;
D O I
暂无
中图分类号
学科分类号
摘要
Objectives: We investigated p53 gene mutations in advanced gastric cancers by direct DNA sequencing, in order to determine the frequency of mutations in gastric cancers having different epidemiological backgrounds, tumors of the cardia were compared with those arising in the antrum or corpus. Intestinal type cancers were compared with diffuse or other histologic types. We have chosen to assess the frequency of mutations solely based on DNA sequencing.
引用
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页码:227 / 231
页数:4
相关论文
共 199 条
  • [1] Landis SH(1998)Cancer Statistics, 1998 CA Cancer J Clin 48 6-29
  • [2] Murray T(1988)A human model for gastric carcinogenesis Cancer Res 48 3544-3560
  • [3] Bolden S(1991) and its relation to stomach cancer in a population of Japanese Americans in Hawaii N Eng J Med 325 1132-1136
  • [4] Wingo PA(1995)Prevalence of Gastroenterology 109 885-888
  • [5] Correa P(1971) infection in subtypes of gastric cancer Int J Cancer 8 144-157
  • [6] Nomura A(1993)Time trends of diffuse and intestinal types of cancer in Norway Cancer 72 330-340
  • [7] Stemmermann GN(1987)The time trend and age-period-cohort effects on incidence of adencarcinoma of the stomach in Connecticut from 2955-89 Cancer 60 1094-1098
  • [8] Chyou P-H(1992)Adenocarcinoma of the esophagus and/or cardia of the stomach Br J Cancer 65 708-710
  • [9] Kato I(1991)p53 mutations in gastric cancer J Natl Cancer Inst 83 938-943
  • [10] Perez-Perez GI(1991)Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines Cancer Res 51 5800-5805