A haplotype derived from the common variants at the −1997G/T and Sp1 binding site of the COL1A1 gene influences risk of postmenopausal osteoporosis in India

被引：0
作者：
Monica Singh
Puneetpal Singh
Surinder Singh
Pawan Kumar Juneja
Taranpal Kaur
机构：
[1] Punjabi University,Molecular Genetics Laboratoty, Department of Human Biology
来源：
Rheumatology International | 2013年 / 33卷
关键词：
COL1A1 gene; rs1107946; rs1800012; Haplotypes; BMD; Postmenopausal women; India;
D O I：
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学科分类号：
摘要：
The aim of the present study was to investigate the association between Collagen 1 alpha 1 (COL1A1) polymorphism and osteoporosis in DEXA verified 349 (145 osteoporotic, 87 osteopenic and 117 normal) postmenopausal women of India, who were not taking hormone replacement therapy. Two single-nucleotide polymorphisms (SNPs), that is, −1997G/T (rs1107946) and +1245G/T (rs1800012, Sp1) of the COL1A1 gene, were analyzed. Minor allele frequencies of rs1107946 and rs1800012 were 0.15 and 0.20 in osteoporotic women, 0.18 and 0.18 in osteopenic and 0.20 and 0.17 in women having normal bone mass. An allele dose effect with BMD of lumbar spine has been exhibited by major allele G of rs1107946 (GG: 0.86 g/cm2, GT: 0.91 g/cm2 and TT: 0.93 g/cm2) and minor allele T of rs1800012 (GG: 0.91 g/cm2, GT: 0.87 g/cm2 and TT: 0.81 g/cm2). Disease association analysis revealed a haplotype GT that confers approximately threefold higher risk of osteoporosis in the carriers (OR 3.12, 95% CI 1.24–8.88, P = 0.008) after adjusting the confounding effect of age, BMI and years since menopause. These results suggest that GT haplotype of COL1A1 gene is associated with a higher risk of postmenopausal osteoporosis in Northwest Indian women.
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页码：501 / 506
页数：5
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