Multilocus Sequence Typing of Clinical Isolates of Cryptococcus from India

被引：0
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作者：
Immaculata Xess
Mragnayani Pandey
Yubhisha Dabas
Reshu Agarwal
Shukla Das
Padma M. V. Srivastava
Rajeev Thakur
Shyama Sharma
Prashant Mani
Ashutosh Biswas
Dipankar Bhowmik
Bimal K. Das
Rakesh Singh
Preetilata Panda
Gagandeep Singh
A. C. Phukan
Margaret Yhome
Chithra Valsan
Anupma Jyoti Kindo
机构：
[1] All India Institute of Medical Sciences (AIIMS),Department of Microbiology
[2] New Delhi,Department of Microbiology
[3] University College of Medical Sciences (UCMS) & Guru TegBahadur (GTB) Hospital,Department of Neurology
[4] New Delhi,Department of Microbiology
[5] All India Institute of Medical Sciences (AIIMS),Department of Medicine
[6] New Delhi,Department of Nephrology
[7] Institute of Human Behavior& Allied Sciences (IHBAS),Department of Microbiology
[8] All India Institute of Medical Sciences (AIIMS),Department of Microbiology
[9] New Delhi,Department of Microbiology
[10] All India Institute of Medical Sciences (AIIMS),Department of Microbiology
[11] New Delhi,Department of Microbiology
[12] Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER),Department of Microbiology
[13] Maharaja Krishna Chandra Gajapati (MKCG) Medical College & Hospital,undefined
[14] North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS),undefined
[15] Naga Hospital Authority Kohima (NHAK),undefined
[16] Jubilee Mission Medical College and Research Institute,undefined
[17] Sri Ramachandra Medical College and Research Institute (SRMC & RI),undefined
来源：
Mycopathologia | 2021年 / 186卷
关键词：
sequence typing (MLST); Antifungal susceptibility; India;
D O I：
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摘要：
Cryptococcosis is a life-threatening infection caused by Cryptococcus neoformans and C. gattii species complex. In the present study, to understand the molecular epidemiology of 208 clinical isolates of Cryptococcus from different parts of India, multilocus sequence typing (MLST) using ISHAM MLST consensus scheme for C. neoformans/C. gattii species complex was used. MLST analysis yielded a total of 10 Sequence Types (STs)—7 STs for C. neoformans and 3 for C. gattii species complex. The majority of isolates identified as C. neoformans belonged to molecular type VNI with predominant STs 31 and 93. Only 3 isolates of C. gattii species complex were obtained, belonging to ST58 and ST215 of VGI and ST69 of VGIV. Phylogenetic analysis revealed less diversity among the clinical Indian isolates compared to the global MLST database. No association between prevalent STs and HIV status, geographical origin or minimum inhibitory concentration (MIC) could be established.
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页码：199 / 211
页数：12
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