Changing phase relationship of the stepping rhythm to neuronal oscillatory theta activity in the septo-hippocampal network of mice

被引:0
作者
Abhilasha Joshi
Peter Somogyi
机构
[1] University of Oxford,Department of Pharmacology
[2] University of California,Department of Physiology, Kavli Institute for Fundamental Neuroscience
来源
Brain Structure and Function | 2020年 / 225卷
关键词
Movement; Medial septum; Stepping rhythm; Theta oscillations; Hippocampus; Navigation;
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暂无
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学科分类号
摘要
Movement-related sensory and motor activity in the brain contributes to cognitive processes. We have observed that the frequency of stepping rhythm in head-fixed mice running on a jetball overlaps with the range of frequencies that characterize hippocampal rhythmic slow activity, including theta (~ 3 to 10 Hz). On average, step-cycle troughs (i.e. when the paw touches the ground) were weakly coupled to hippocampal theta oscillations. This weak coupling was sustained during a range of running speeds. In short temporal windows, step-cycle troughs were synchronous with hippocampal theta oscillatory cycle troughs, while during other periods they led or lagged behind theta cycles. Furthermore, simultaneously recorded theta rhythmic medial septal neurons in the basal forebrain were phase-coupled to both step-cycles and theta-cycles. We propose that the weak overall phase relationship of step-cycles with theta-cycles signifies a distinct mode of information processing. Transient synchronization of the step-cycle with theta may indicate the engagement of septo-hippocampal-entorhinal network with the current heading of the animal.
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页码:871 / 879
页数:8
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