The role of extracellular vesicles in cholangiocarcinoma

被引：0

作者：

Mingzhen Bai

Wenkang Fu

Gang Su

Jie Cao

Long Gao

Chongfei Huang

Haidong Ma

Jinduo Zhang

Ping Yue

Bing Bai

Yanyan Lin

Wenbo Meng

Xun Li

机构：

[1] Lanzhou University,The First Clinical Medical College

[2] The First hospital of Lanzhou University,Department of Special Minimally Invasive Surgery

[3] The First Hospital of Lanzhou University,Division of Scientific Research and Development Planning

[4] Lanzhou University,Institute of Genetics, School of Basic Medical Sciences

[5] Gansu Province Institute of Hepatopancreatobiliary,The Second Department of General Surgery

[6] Gansu Province Key Laboratory Biotherapy and Regenerative Medicine,undefined

[7] The First Hospital of Lanzhou University,undefined

来源：

Cancer Cell International | / 20卷

关键词：

Cholangiocarcinoma; Extracellular vesicles; Exosomes; Biomarkers; Therapy;

D O I：

暂无

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学科分类号：

摘要：

Cholangiocarcinoma (CCA) is a rare tumor that arises from cholangiocytes, the epithelial cells of the bile duct. The tumor is characterized by insidious onset, high degree of malignancy, poor prognosis and high recurrence rate. Due to the lack of specific biomarkers, it is difficult to diagnose CCA early and evaluate prognosis. Extracellular vesicles (EVs), which include apoptotic bodies, microvesicles and exosomes, have emerged as having important roles in cell-to-cell communication in both normal physiology and pathological conditions. Some research has found that EVs play a crucial role in the occurrence and development of CCA. EVs can carry specific molecular substances such as nucleic acids and proteins, which have potential for the diagnosis and therapy of CCA. This article reviews the current knowledge on the role of EVs in CCA. We highlight EVs and their functions in the physiology and pathophysiology of CCA, and discuss their therapeutic potential and their role as biomarkers.

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