Current understanding of epigenetics role in melanoma treatment and resistance

被引：0
作者：
Mohsen Karami Fath
Ali Azargoonjahromi
Asma Soofi
Faezeh Almasi
Shahnaz Hosseinzadeh
Saeed Khalili
Kamran Sheikhi
Saeid Ferdousmakan
Soroor Owrangi
Minoovash Fahimi
Hamidreza Zalpoor
Mohsen Nabi Afjadi
Zahra Payandeh
Navid Pourzardosht
机构：
[1] Kharazmi University,Department of Cellular and Molecular Biology, Faculty of Biological Sciences
[2] Shiraz University of Medical Sciences,Department of Physical Chemistry, School of Chemistry, College of Sciences
[3] University of Tehran,Pharmaceutical Biotechnology Lab, Department of Microbial Biotechnology, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science
[4] University of Tehran,Department of Microbiology, Parasitology and Immunology
[5] Ardabil University of Medical Sciences,Department of Biology Sciences
[6] Shahid Rajaee Teacher Training University,School of Medicine
[7] Kurdistan University of Medical Sciences,Department of Pharmacy Practice
[8] Nargund College of Pharmacy,Student Research Committe
[9] Fasa University of Medical Sciences,Faculty of Medicine
[10] Comenius University,Shiraz Neuroscience Research Center
[11] Shiraz University of Medical Sciences,Network of Immunity in Infection
[12] Malignancy & Autoimmunity (NIIMA),Department of Biochemistry, Faculty of Biological Science
[13] Universal Scientific Education & Research Network (USERN),Department Medical Biochemistry and Biophysics, Division Medical Inflammation Research
[14] Tarbiat Modares University,Biochemistry Department
[15] Karolinska Institute,undefined
[16] Guilan University of Medical Sciences,undefined
来源：
Cancer Cell International | / 22卷
关键词：
Melanoma; Epigenetics; Drug resistance; Immunotherapy;
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摘要：
Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in melanocytes. Several factors have been considered to be involved in melanoma progression, including genetic alteration, processes of damaged DNA repair, and changes in mechanisms of cell growth and proliferation. Epigenetics is the other factor with a crucial role in melanoma development. Epigenetic changes have become novel targets for treating patients suffering from melanoma. These changes can alter the expression of microRNAs and their interaction with target genes, which involves cell growth, differentiation, or even death. Given these circumstances, we conducted the present review to discuss the melanoma risk factors and represent the current knowledge about the factors related to its etiopathogenesis. Moreover, various epigenetic pathways, which are involved in melanoma progression, treatment, and chemo-resistance, as well as employed epigenetic factors as a solution to the problems, will be discussed in detail.
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