Philadelphia chromosome-positive acute lymphoblastic leukemia: Impact of imatinib treatment on remission induciton and allogeneic stem cell tranplantation

被引：3
作者：
Kovacsovics T. [1 ]
Maziarz R.T. [1 ]
机构：
[1] Center for Hematologic Malignancies, Oregon Health Science University, Portland, OR 97239-3098
来源：
Current Oncology Reports | 2006年 / 8卷 / 5期
关键词：
Imatinib; Chronic Myeloid Leukemia; Dasatinib; Imatinib Mesylate; Allogeneic Stem Cell Transplantation;
D O I：
10.1007/s11912-006-0056-y
中图分类号：
学科分类号：
摘要：
Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) has been associated with the worst patient survival rates of the various acute leukemias. Imatinib mesylate is a novel therapeutic agent that targets the BCR-ABL tyrosine kinase, the molecular abnormality associated with Ph+ ALL. The combination of imatinib with chemotherapy has led to improved and durable treatment responses in adult patients with Ph+ ALL, including the elderly population. Hematopoietic stem cell transplantation has also integrated imatinib into its transplant strategies, with early data suggesting improved progression-free survival without clearly identifiable augmented toxicity. Second-generation tyrosine kinase inhibitors offer potentially even greater improvements on these excellent imatinib-associated outcomes. This review addresses the evolution of the management of Ph+ ALL and is intended to assist in the description of its new natural history. Copyright © 2006 by Current Science Inc.
引用
收藏
页码：343 / 351
页数：8
相关论文
共 61 条
  • [1] Gleissner B., Gokbuget N., Bartram C.R., Et al., Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: A prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis, Blood, 99, pp. 1536-1543, (2002)
  • [2] Dombret H., Gabert J., Boiron J.M., Et al., Outcome of treatment in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia - Results of the prospective multicenter LALA-94 trial, Blood, 100, pp. 2357-2366, (2002)
  • [3] Goldstone A.H., Prentice H.G., Durrant J., Et al., Allogeneic transplant (related or unrelated donor) is the preferred treatment for adult Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia (ALL), Blood, 98, (2001)
  • [4] Kantarjian H.M., O'Brien S., Smith T.L., Et al., Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia, J Clin Oncol, 18, 3, pp. 547-561, (2000)
  • [5] Avivi I., Goldstone A.H., Bone marrow transplant in Ph+ ALL patients, Bone Marrow Transplant, 31, pp. 623-632, (2003)
  • [6] Yanada M., Naoe T., Iida H., Et al., Myeloablative allogeneic hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia in adults: Significant roles of total body irradiation and chronic graft-versus-host disease, Bone Marrow Transplant, 36, pp. 867-872, (2005)
  • [7] Cornelissen J.J., Carston M., Kollman C., Et al., C: Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: Strong graft-versus-leukemia effect and risk factors determining outcome, Blood, 97, pp. 1572-1577, (2001)
  • [8] Kiehl M.G., Kraut L., Schwerdtfeger R., Et al., Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: No difference in related compared with unrelated transplant in first complete remission, J Clin Oncol, 22, pp. 2816-2825, (2004)
  • [9] Stirewalt D.L., Guthrie K.A., Beppu L., Et al., Predictors of relapse and overall survival in Philadelphia chromosome-positive acute lymphoblastic leukemia after transplantation, Biol Blood Marrow Transplant, 9, pp. 206-212, (2003)
  • [10] Esperou H., Boiron J.M., Cayuela, Et al., A potential graft-versus-leukemia effect after allogeneic hematopoietic stem cell transplantation for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: Results from the French Bone Marrow Transplantation Society, Bone Marrow Transplant, 31, pp. 909-918, (2003)
1234567