Modularity of MAP kinases allows deformation of their signalling pathways

被引：0
作者：
Areez Mody
Joan Weiner
Sharad Ramanathan
机构：
[1] FAS Center for Systems Biology,Department of Molecular and Cellular Biology
[2] Harvard University,undefined
[3] Harvard University,undefined
[4] School of Engineering and Applied Sciences,undefined
[5] Harvard University,undefined
[6] Harvard Stem Cell Institute,undefined
[7] Havard University,undefined
来源：
Nature Cell Biology | 2009年 / 11卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
During evolution, MAP kinases repeatedly changed substrate specificities and interaction partners. Because of their modular design, they can be experimentally re-designed to achieve rewiring of the signalling network.
引用
收藏
页码：484 / 491
页数：7
相关论文
共 80 条
[1]  
Manning G(2002)Evolution of protein kinase signaling from yeast to man Trends Biochem. Sci. 27 514-520
[2]  
Plowman GD(2004)Robustness of cellular functions Cell 118 675-685
[3]  
Hunter T(2003)Evolutionary conservation of motif constituents in the yeast protein interaction network Nature Genet. 35 176-179
[4]  
Sudarsanam S(1998)Signalling in the yeasts: an informational cascade with links to the filamentous fungi Microbiol. Mol. Biol. Rev. 62 249-274
[5]  
Stelling J(2001)Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation Mol. Cell 8 683-691
[6]  
Sauer U(2002)Functional profiling of the Nature 418 387-391
[7]  
Szallasi Z(2000) genome Genome Biol. 1 R1011-1543
[8]  
Doyle FJ(2008)Where does fission yeast sit on the tree of life? Science 319 1539-826
[9]  
Doyle J(2006)Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics Science 311 822-962
[10]  
Wuchty S(2005)The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway Mol. Cell 20 951-3650
12345678