Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile

被引：0
作者：
Marta Milà-Alomà
Mahnaz Shekari
Gemma Salvadó
Juan Domingo Gispert
Eider M. Arenaza-Urquijo
Grégory Operto
Carles Falcon
Natalia Vilor-Tejedor
Oriol Grau-Rivera
Aleix Sala-Vila
Gonzalo Sánchez-Benavides
José Maria González-de-Echávarri
Carolina Minguillon
Karine Fauria
Aida Niñerola-Baizán
Andrés Perissinotti
Maryline Simon
Gwendlyn Kollmorgen
Henrik Zetterberg
Kaj Blennow
Marc Suárez-Calvet
José Luis Molinuevo
机构：
[1] Pasqual Maragall Foundation,Barcelonaβeta Brain Research Center (BBRC)
[2] IMIM (Hospital del Mar Medical Research Institute),Centro de Investigación Biomédica en Red Bioingeniería
[3] Universitat Pompeu Fabra,Centre for Genomic Regulation (CRG)
[4] Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES),Department of Clinical Genetics
[5] Biomateriales y Nanomedicina,Servei de Neurologia
[6] The Barcelona Institute for Science and Technology,Servei de Medicina Nuclear
[7] ERASMUS MC,Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology
[8] Hospital del Mar,Clinical Neurochemistry Laboratory
[9] Hospital Clínic,Department of Neurodegenerative Disease
[10] Roche Diagnostics International Ltd.,undefined
[11] Roche Diagnostics GmbH,undefined
[12] University of Gothenburg,undefined
[13] Sahlgrenska University Hospital,undefined
[14] UCL Institute of Neurology,undefined
[15] UK Dementia Research Institute at UCL,undefined
[16] Present address: H. Lundbeck A/S,undefined
来源：
Alzheimer's Research & Therapy | / 13卷
关键词：
Preclinical; Alzheimer’s disease; CSF; Biomarkers; Subthreshold; Cognitively unimpaired;
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  • [11] Cappa S(2019)Subthreshold amyloid and its biological and clinical meaning Neurology. 93 72-e1460
  • [12] Crutch S(2018)Subthreshold amyloid predicts tau deposition in aging J Neurosci 38 4482-2566
  • [13] Engelborghs S(2018)Memory decline accompanies subthreshold amyloid accumulation Neurology. 90 e1452-367
  • [14] Frisoni GB(2016)Amyloid deposition in younger adults is linked to episodic memory performance Neurology 87 2562-896
  • [15] Fox NC(2013)Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study Lancet Neurol 12 357-216
  • [16] Galasko D(2013)Brain β-amyloid load approaches a plateau Neurology 80 890-879
  • [17] Habert MO(2017)Defining imaging biomarker cut points for brain aging and Alzheimer’s disease Alzheimers Dement 13 205-92
  • [18] Jicha GA(2018)Longitudinal decreases in multiple cerebrospinal fluid biomarkers of neuronal injury in symptomatic late onset Alzheimer’s disease Alzheimers Dement 14 869-292
  • [19] Nordberg A(2016)The ALFA project: a research platform to identify early pathophysiological features of Alzheimer’s disease Alzheimers Dement 2 82-1371
  • [20] Pasquier F(2014)Biobanking of CSF: international standardization to optimize biomarker development Clin Biochem 47 288-38
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