Vitamin D and type 2 diabetes

被引：13

作者：

Eliades M. ^{[1
]}

Pittas A.G. ^{[1
]}

机构：

[1] Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, 800 Washington Street

来源：

Clinical Reviews in Bone and Mineral Metabolism | 2009年 / 7卷 / 2期

关键词：

Calcium; Type; 2; diabetes; Vitamin D;

D O I：

10.1007/s12018-009-9041-y

中图分类号：

学科分类号：

摘要：

Vitamin D has been reported to have a variety of non-skeletal actions, including on glucose metabolism. There has been increasing evidence from animal and human studies, to suggest that vitamin D may be important in modifying risk of type 2 diabetes. Vitamin D is thought to have both direct (through activation of the vitamin D receptor) and indirect (via regulation of calcium homeostasis) effects on various mechanisms related to the pathophysiology of type 2 diabetes, including pancreatic beta-cell dysfunction, impaired insulin action, and systemic inflammation. The evidence from human studies comes primarily from cross-sectional and a few prospective observational studies showing an inverse association between vitamin D status and prevalence or incidence of type 2 diabetes. While there is paucity of trials that have specifically examined the role of vitamin D in prevention or treatment of type 2 diabetes, vitamin D therapy is emerging as a feasible and cost-effective potential intervention for type 2 diabetes. © Humana Press Inc. 2009.

引用

页码：185 / 198

页数：13

共 96 条

[61]

Pietschmann P., Schernthaner G., Woloszczuk W., Serum osteocalcin levels in diabetes mellitus: Analysis of the type of diabetes and microvascular complications, Diabetologia, 31, 12, pp. 892-895, (1988)

[62]

Scragg R., Et al., Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus, Diabetes Res Clin Pract, 27, 3, pp. 181-188, (1995)

[63]

Stepan J., Wilczek H., Justova V., Plasma 25-hydroxycholecalciferol in oral sulfonylurea treated diabetes mellitus, Hormone and Metabolic Research, 14, 2, pp. 98-100, (1982)

[64]

Heath III H., Et al., Calcium homeostasis in diabetes mellitus, J Clin Endocrinol Metab, 49, 3, pp. 462-466, (1979)

[65]

Ishida H., Seino Y., Matsukura S., Diabetic osteopenia and circulating levels of vitamin D metabolites in type 2 (noninsulin-dependent) diabetes, Metabolism: Clinical and Experimental, 34, 9, pp. 797-801, (1985)

[66]

Baynes K.C.R., Boucher B.J., Feskens E.J.M., Kromhout D., Vitamin D, glucose tolerance anal insulinaemia in elderly men, Diabetologia, 40, 3, pp. 344-347, (1997)

[67]

Chiu K.C., Chu A., Go V.L.W., Saad M.F., Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction, American Journal of Clinical Nutrition, 79, 5, pp. 820-825, (2004)

[68]

Ford E.S., Ajani U.A., McGuire L.C., Liu S., Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults, Diabetes Care, 28, 5, pp. 1228-1230, (2005)

[69]

Martins D., Wolf M., Pan D., Zadshir A., Tareen N., Thadhani R., Felsenfeld A., Levine B., Mehrotra R., Norris K., Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: Data from the Third National Health and Nutrition Examination Survey, Archives of Internal Medicine, 167, 11, pp. 1159-1165, (2007)

[70]

Need A.G., O'Loughlin P.D., Horowitz M., Nordin B.E.C., Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women, Clinical Endocrinology, 62, 6, pp. 738-741, (2005)

← 1 2 3 4 5 6 7 8 9 10 →