Vitamin D and type 2 diabetes

被引：13
作者：
Eliades M. [1 ]
Pittas A.G. [1 ]
机构：
[1] Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, 800 Washington Street
来源：
Clinical Reviews in Bone and Mineral Metabolism | 2009年 / 7卷 / 2期
关键词：
Calcium; Type; 2; diabetes; Vitamin D;
D O I：
10.1007/s12018-009-9041-y
中图分类号：
学科分类号：
摘要：
Vitamin D has been reported to have a variety of non-skeletal actions, including on glucose metabolism. There has been increasing evidence from animal and human studies, to suggest that vitamin D may be important in modifying risk of type 2 diabetes. Vitamin D is thought to have both direct (through activation of the vitamin D receptor) and indirect (via regulation of calcium homeostasis) effects on various mechanisms related to the pathophysiology of type 2 diabetes, including pancreatic beta-cell dysfunction, impaired insulin action, and systemic inflammation. The evidence from human studies comes primarily from cross-sectional and a few prospective observational studies showing an inverse association between vitamin D status and prevalence or incidence of type 2 diabetes. While there is paucity of trials that have specifically examined the role of vitamin D in prevention or treatment of type 2 diabetes, vitamin D therapy is emerging as a feasible and cost-effective potential intervention for type 2 diabetes. © Humana Press Inc. 2009.
引用
收藏
页码：185 / 198
页数：13
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