Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2

被引：0

作者：

Anna Marie Mulligan

Fergus J Couch

Daniel Barrowdale

Susan M Domchek

Diana Eccles

Heli Nevanlinna

Susan J Ramus

Mark Robson

Mark Sherman

Amanda B Spurdle

Barbara Wappenschmidt

Andrew Lee

Lesley McGuffog

Sue Healey

Olga M Sinilnikova

Ramunas Janavicius

Thomas vO Hansen

Finn C Nielsen

Bent Ejlertsen

Ana Osorio

Iván Muñoz-Repeto

Mercedes Durán

Javier Godino

Maroulio Pertesi

Javier Benítez

Paolo Peterlongo

Siranoush Manoukian

Bernard Peissel

Daniela Zaffaroni

Elisa Cattaneo

Bernardo Bonanni

Alessandra Viel

Barbara Pasini

Laura Papi

Laura Ottini

Antonella Savarese

Loris Bernard

Paolo Radice

Ute Hamann

Martijn Verheus

Hanne EJ Meijers-Heijboer

Juul Wijnen

Encarna B Gómez García

Marcel R Nelen

C Marleen Kets

Caroline Seynaeve

Madeleine MA Tilanus-Linthorst

Rob B van der Luijt

Theo van Os

Matti Rookus

机构：

[1] St Michael's Hospital,Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute

[2] Mayo Clinic,Department of Laboratory Medicine and Pathology

[3] Centre for Cancer Genetic Epidemiology,Department of Medicine

[4] Department of Public Health and Primary Care,Department of Obstetrics and Gynecology

[5] University of Cambridge,Department of Preventive Medicine

[6] Abramson Cancer Center,Department of Medicine

[7] Perelman School of Medicine at the University of Pennsylvania,Department of Molecular and Regenerative Medicine

[8] Faculty of Medicine,Department of Oncology

[9] University of Southampton,Division of Cancer Prevention and Genetics

[10] University Hospital Southampton NHS Foundation Trust,Department of Genetics

[11] University of Helsinki and Helsinki University Central Hospital,Department of Molecular Medicine

[12] Keck School of Medicine,Division of Medical Oncology

[13] University of Southern California,Department of Experimental Oncology

[14] Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College,Department of Epidemiology

[15] National Cancer Institute,Department of Clinical Genetics

[16] Division of Cancer Epidemiology and Genetics,Department of Human Genetics and Department of Clinical Genetics

[17] Hormonal and Reproductive Epidemiology Branch,Department of Clinical Genetics and GROW

[18] Queensland Institute of Medical Research,Department of Human Genetics 849

[19] Centre of Familial Breast and Ovarian Cancer,Department of Human Genetics 836

[20] Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO),Department of Medical Oncology

[21] University Hospital of Cologne,Department of Surgical Oncology

[22] Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents,Department of Medical Genetics

[23] Centre Hospitalier Universitaire de Lyon/Centre Léon Bérard,Department of Clinical Genetics

[24] INSERM U1052,Department of Pathology and Laboratory Medicine

[25] CNRS UMR5286,Department of Gynaecology and Obstetrics, Division of Tumour Genetics

[26] Université Lyon 1,Department of Gynaecology and Obstetrics

[27] Cancer Research Center of Lyon,Department of Gynaecology and Obstetrics

[28] Hematology,Department of Gynaecology and Obstetrics

[29] Oncology and Transfusion Medicine Center,Department of Gynaecology and Obstetrics

[30] Vilnius University Hospital Santariskiu Clinics,Department of Gynaecology and Obstetrics

[31] Santariskiu st 2,Department of Clinical Genetics

[32] LT-08661 Vilnius and State Research Institute Innovative Medicine Center,Department of Pathology

[33] Center for Genomic Medicine,Department of Oncology and Surgical Sciences

[34] Rigshospitalet,Department of Anatomical Pathology

[35] Copenhagen University Hospital,Departments of Medicine

[36] Rigshospitalet Bldg. 4262,Department of Internal Medicine and Harold C. Simmons Comprehensive Cancer Center

[37] Copenhagen University Hospital,Department of Health Sciences Research

[38] Human Genetics Group,Department of Medical Genetics

[39] Human Cancer Genetics Programme,Department of Obstetrics/Gynaecology and Comprehensive Cancer Center

[40] Spanish National Cancer Research Centre and the Spanish Network on Rare Diseases (CIBERER),Department of Laboratory Medicine and Pathobiology

[41] Institute of Biology and Molecular Genetics,Departments of Molecular Virology

[42] Universidad de Valladolid (IBGM-UVA),Department of Clinical Genetics

[43] C/Sanz y Forés,Department of Clinical Genetics

[44] Instituto de investigación sanitaria de Aragón (IIS),Department of Oncology

[45] Hospital clinico Universitario "Lozano Blesa",Division of Clinical Genetics

[46] Molecular Diagnostics Laboratory,Department of Oncology

[47] IRRP,Department of Population Sciences

[48] National Center for Scientific Research Demokritos,Department of Oncology

[49] Human Genetics Group and Genotyping Unit,Department of Cancer Prevention and Control

[50] Human Cancer Genetics Programme,Department of Epidemiology

来源：

Breast Cancer Research | / 13卷

关键词：

Breast Cancer; Breast Cancer Risk; Mutation Carrier; Estrogen Receptor Status; BRCA2 Mutation Carrier;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 950 条

[1]

Ford D(1994)Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium Lancet 343 692-695

[2]

Easton DF(1999)Cancer risks in BRCA2 mutation carriers J Natl Cancer Inst 91 1310-1316

[3]

Bishop DT(2002)Cancer incidence in BRCA1 mutation carriers J Natl Cancer Inst 94 1358-1365

[4]

Narod SA(2010)Familial relative risks for breast cancer by pathological subtype: a population-based cohort study Breast Cancer Res 12 R10-236

[5]

Goldgar DE(2004)The genetic epidemiology of breast cancer genes J Mammary Gland Biol Neoplasia 9 221-1130

[6]

Thompson D(2003)Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies Am J Hum Genet 72 1117-201

[7]

Easton DF(2008)Variation of breast cancer risk among BRCA1/2 carriers JAMA 299 194-689

[8]

Mavaddat N(1998)Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium Am J Hum Genet 62 676-747

[9]

Pharoah PD(1999)Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of protein-truncating mutations in BRCA1 and BRCA2. Australian Breast Cancer Family Study Cancer Epidemiol Biomarkers Prev 8 741-2869

[10]

Blows F(2008)The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain Clin Cancer Res 14 2861-3774

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