Characterization of thermo-sensitive hydrogels based on poly(N-isopropylacrylamide)/hyaluronic acid

被引：0

作者：

Ramón Coronado

Sara Pekerar

Arnaldo T. Lorenzo

Marcos A. Sabino

机构：

[1] Universidad Simón Bolívar,B5IDA Group, Department of Chemistry

[2] IVIC,USB Polymer Group, Department of Materials Science

[3] Venezuelan Institute of Scientific Research,undefined

[4] Chemistry Center,undefined

[5] Universidad Simón Bolívar,undefined

来源：

Polymer Bulletin | 2011年 / 67卷

关键词：

Poly-NIPA; Hyaluronic acid; Thermo-sensitive; Interpenetrating polymer network; Injectable hydrogel;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

In this study, an hydrogel was synthesized from the monomer N-isopropylacrylamide (NIPA), generating the poly(N-isopropylacrylamide) (PNIPA) and other formulations were synthesized in the presence of 1, 2, and 3% hyaluronic acid (HA) for obtain an interpenetrating polymer network. For all the obtained hydrogels, the thermo-sensitive response was studied since the lower critical solution temperature (LCST) and was analyzed by differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and oscillatory rheology at constant frequency as a function of temperature. The LCST transition temperature (Ttonset) was found between 34.4 and 35.5 °C. By scanning electron microscopy (SEM) PNIPA-HA formulations showed a porous morphology. The applicability of the hydrogels as injectable and non-toxic materials was verified, respectively, by rheology results and by cytotoxicity studies through an in vitro test of cell hemolysis on blood agar.

引用

页码：101 / 124

页数：23

共 50 条

[21] Synthesis and characterization of non-toxic and thermo-sensitive poly(N-isopropylacrylamide)-grafted cashew gum nanoparticles as a potential epirubicin delivery matrix [J].

Abreu, Clara M. W. S. ;

Paula, Haroldo C. B. ;

Seabra, Vitor ;

Feitosa, Judith P. A. ;

Sarmento, Bruno ;

de Paula, Regina C. M. .

CARBOHYDRATE POLYMERS, 2016, 154 :77-85

[22] Thermo-responsive poly(N-isopropylacrylamide)-hyaluronic acid nano-hydrogel and its multiple applications [J].

Xu, Lifeng ;

Zhong, Shuangling ;

Gao, Yan ;

Cui, Xuejun .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 194 :811-818

[23] New Thermo-responsive Hydrogels Based on Poly (N-isopropylacrylamide)/Hyaluronic Acid Semi-interpenetrated Polymer Networks: Swelling Properties and Drug Release Studies [J].

Santos, Joao R. ;

Alves, Natalia M. ;

Mano, Joao F. .

JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 2010, 25 (02) :169-184

[24] Influence of pore size and pore shape on thermo-sensitive properties of poly[(ethylene terephthalate)-graft-(N-isopropylacrylamide)] track membranes [J].

Liu, Qi ;

Yang, Xiaomin ;

Chen, Xiliang ;

Ma, Mingwang ;

Yang, Kang ;

Liu, Dan ;

Zhu, Zhiyong .

POLYMER INTERNATIONAL, 2009, 58 (09) :1078-1083

[25] Temperature-pH Sensitive IPN Hydrogels Composed of Silk Sericin and Poly (N-isopropylacrylamide) [J].

Wen WU Wen Jing LI Li Qun WANG Ke Hua TU Wei Lin SUN Department of Polymer Science and Engineering Zhejiang University Hangzhou Ningbo Institute of Technology Zhejiang University Ningbo .

Chinese Chemical Letters, 2006, (03) :403-406

[26] A novel polyurethane-modified poly(N-isopropylacrylamide) hydrogels [J].